A Clear Cell Tumor of the Lung Presenting as a Rapidly Growing Coin Lesion: Is It Really a Benign Tumor? Alexandros Kalkanis, MD, Myrto Trianti, MD,

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Presentation transcript:

A Clear Cell Tumor of the Lung Presenting as a Rapidly Growing Coin Lesion: Is It Really a Benign Tumor? Alexandros Kalkanis, MD, Myrto Trianti, MD, Kostas Psathakis, MD, Charalampos Mermigkis, MD, Dimitrios Kalkanis, MD, Grigorios Karagkiouzis, MD, Anna Razou, MD, Kostas Tsintiris, MD The Annals of Thoracic Surgery Volume 91, Issue 2, Pages 588-591 (February 2011) DOI: 10.1016/j.athoracsur.2010.07.043 Copyright © 2011 The Society of Thoracic Surgeons Terms and Conditions

Fig 1 A coin lesion can be seen in the left lower lung field (arrow) of this chest roentgenogram. The Annals of Thoracic Surgery 2011 91, 588-591DOI: (10.1016/j.athoracsur.2010.07.043) Copyright © 2011 The Society of Thoracic Surgeons Terms and Conditions

Fig 2 A computed tomography scan of the chest demonstrates a solitary round, not enhancing 2-cm-diameter homogenous nodule at the lingula (arrow). The Annals of Thoracic Surgery 2011 91, 588-591DOI: (10.1016/j.athoracsur.2010.07.043) Copyright © 2011 The Society of Thoracic Surgeons Terms and Conditions

Fig 3 A technetium 99m-depreotide scan demonstrates a selective radiotracer uptake at the lingula, consistent with a somatostatin receptor-positive lesion. The Annals of Thoracic Surgery 2011 91, 588-591DOI: (10.1016/j.athoracsur.2010.07.043) Copyright © 2011 The Society of Thoracic Surgeons Terms and Conditions

Fig 4 Pathologic examination revealed a clear cell tumor that consisted of (A) (magnification ×100, stain hematoxylin-eosin) rounded and oval cells with abundant clear cytoplasm, (B) (magnification ×200, stain hematoxylin-eosin) distinct cells borders, and (C) (magnification ×400, stain hematoxylin-eosin) cytoplasm rich in glycogen granules positive for periodic acid-Schiff. (D) (magnification ×400, stain hematoxylin-eosin). Many of the tumor cells had positive immunoreactivity for human melanoma black-45. The Annals of Thoracic Surgery 2011 91, 588-591DOI: (10.1016/j.athoracsur.2010.07.043) Copyright © 2011 The Society of Thoracic Surgeons Terms and Conditions