Inside Out: Bone Marrow Necrosis and Fat Embolism Complicating Sickle-β+ Thalassemia Jori May, MD, Joseph C. Sullivan, MD, Daniel LaVie, MD, Katherine.

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Presentation transcript:

Inside Out: Bone Marrow Necrosis and Fat Embolism Complicating Sickle-β+ Thalassemia Jori May, MD, Joseph C. Sullivan, MD, Daniel LaVie, MD, Katherine LaVie, MD, Marisa B. Marques, MD The American Journal of Medicine Volume 129, Issue 12, Pages e321-e324 (December 2016) DOI: 10.1016/j.amjmed.2016.05.027 Copyright © 2016 Elsevier Inc. Terms and Conditions

Figure 1 Magnetic resonance imaging obtained on day 1. (A) Diffusion-weighted image revealed innumerable punctate foci with concordant decreased signal on apparent diffusion coefficient maps (not shown) not conforming to a typical vascular territory, referred to as a “starfield” appearance. (B) Fluid attenuation inversion recovery demonstrated moderate concordance, indicating a subacute pattern mixed with other chronic white matter changes. The American Journal of Medicine 2016 129, e321-e324DOI: (10.1016/j.amjmed.2016.05.027) Copyright © 2016 Elsevier Inc. Terms and Conditions

Figure 2 Reconstruction images from CT of the abdomen and pelvis show femoral head osteonecrosis. The American Journal of Medicine 2016 129, e321-e324DOI: (10.1016/j.amjmed.2016.05.027) Copyright © 2016 Elsevier Inc. Terms and Conditions

Figure 3 Platelet count and renal recovery after exchange transfusion. The American Journal of Medicine 2016 129, e321-e324DOI: (10.1016/j.amjmed.2016.05.027) Copyright © 2016 Elsevier Inc. Terms and Conditions