Crossing the Exon Molecular Cell

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Presentation transcript:

Crossing the Exon Molecular Cell Alberto Moldón, Charles Query Molecular Cell Volume 38, Issue 2, Pages 159-161 (April 2010) DOI: 10.1016/j.molcel.2010.04.010 Copyright © 2010 Elsevier Inc. Terms and Conditions

Figure 1 Schematic Pathway of Exon-Defined Spliceosome Assembly (1) U2 snRNP binds upstream of the exon at the BS, and U1 snRNP binds to the downstream 5′SS; SR proteins bound to ESE stabilize the cross-exon A-like complex. (2) The U4/U6-U5 tri-snRNP binds the complex, forming the cross-exon B-like complex. (3) U6 interacts with the upstream 5′SS, allowing a switch from the cross-exon to the cross-intron structure. (4) Conformational rearrangements (release of U1 and U4) lead to formation of activated B∗ complex. (5) Catalytic steps of the reaction and release of products. Double-headed black arrows denote interactions. SS, splice site; BS, branch site; ESE, exonic splicing enhancer. Molecular Cell 2010 38, 159-161DOI: (10.1016/j.molcel.2010.04.010) Copyright © 2010 Elsevier Inc. Terms and Conditions