Foxf2: A Mesenchymal Regulator of Intestinal Adenoma Development

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Foxf2: A Mesenchymal Regulator of Intestinal Adenoma Development Gijs R. van den Brink  Gastroenterology  Volume 144, Issue 5, Pages 873-876 (May 2013) DOI: 10.1053/j.gastro.2013.03.016 Copyright © 2013 AGA Institute Terms and Conditions

Figure 1 Mesenchymal FoxF2 regulates intestinal epithelial proliferation and modulates adenoma initiation and growth in Apcmin/+ mice. Epithelial–mesenchymal cross-talk plays a critical role in crypt–villus morphogenesis. Hedgehog signals to mesenchyme. Bmps and FoxF1/F2 are key mesenchymal factors that cross-talk to epithelium. Reduced FoxF1/F2 expression results in increased proliferation and increased Wnt signaling during villus morphogenesis (bottom left), and FoxF2 gene dosage of regulates adenoma initiation and growth (top right). Gastroenterology 2013 144, 873-876DOI: (10.1053/j.gastro.2013.03.016) Copyright © 2013 AGA Institute Terms and Conditions

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