Linking Inflammasome Activation and Phagosome Maturation

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Linking Inflammasome Activation and Phagosome Maturation Vanja Lazarevic, Fabio Martinon Cell Host & Microbe Volume 3, Issue 4, Pages 199-200 (April 2008) DOI: 10.1016/j.chom.2008.03.006 Copyright © 2008 Elsevier Inc. Terms and Conditions

Figure 1 Mycobacterial Disruption of Inflammasome Activation and Phagosome Maturation Infection with M. tuberculosis triggers IPAF inflammasome including the adaptor ASC and caspase-1 (Casp-1) (1). Inflammasome activation results in IL-1β processing and release of IL-1β that is followed by the engagement of its receptor (IL-1R) (2). IL-1R signaling promotes phagosome maturation that ultimately leads to phagolysosome fusion and bacterial degradation (3). M. tuberculosis encoding the zmp1 gene prevents phagosome maturation by inhibiting inflammasome activation, thus increasing M. tuberculosis survival. Cell Host & Microbe 2008 3, 199-200DOI: (10.1016/j.chom.2008.03.006) Copyright © 2008 Elsevier Inc. Terms and Conditions