Antiviral Immunity and Circular RNA: No End in Sight

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Antiviral Immunity and Circular RNA: No End in Sight Cristhian Cadena, Sun Hur Molecular Cell Volume 67, Issue 2, Pages 163-164 (July 2017) DOI: 10.1016/j.molcel.2017.07.005 Copyright © 2017 Elsevier Inc. Terms and Conditions

Figure 1 CircRNAs and Antiviral Immunity (A) Schematic of circRNA biogenesis. (B) CircRNAs from virus, but not host, are recognized by the host antiviral immune receptor RIG-I. This is because circRNA has an intrinsic ability to stimulate RIG-I, and the host circRNAs evade the recognition using the protein-binding partners. (C) Antiviral dsRNA-binding proteins, NF90/110, stabilize the intronic RNA secondary structure that promotes circRNA biogenesis. NF90/110 also serve as global regulators of circRNA biogenesis by lowering its nuclear level during viral infection. Molecular Cell 2017 67, 163-164DOI: (10.1016/j.molcel.2017.07.005) Copyright © 2017 Elsevier Inc. Terms and Conditions