A clinically applicable method for long-term salvage of postischemic skeletal muscle Barry Rubin, MD, CM, Jacques Tittley, MD, FRCS(C), Gordon Chang,

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Presentation transcript:

A clinically applicable method for long-term salvage of postischemic skeletal muscle Barry Rubin, MD, CM, Jacques Tittley, MD, FRCS(C), Gordon Chang, MSc, PhD, Andrew Smith, MD, Shinta Liauw, MSc, Alexander Romaschin, PhD, Paul M. Walker, MD, PhD, FRCS(C) Journal of Vascular Surgery Volume 13, Issue 1, Pages 58-68 (January 1991) DOI: 10.1016/0741-5214(91)90012-J Copyright © 1991 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 1 Skeletal muscle necrosis after 5 hours of ischemia and 48 hours of reperfusion (control) or 40 minutes of reperfusion with RBC/Hespan and 47 hours and 20 minutes of unaltered reperfusion (modified reperfusion) *p < 0.0025, paired t test. Journal of Vascular Surgery 1991 13, 58-68DOI: (10.1016/0741-5214(91)90012-J) Copyright © 1991 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 2 Relationship of percent necrosis in controls (x) versus percent salvage (y) in paired contralateral treatment muscles. y = −2.91(x) + 206.7, linear regression, r = 0.94, p = 0.005. Journal of Vascular Surgery 1991 13, 58-68DOI: (10.1016/0741-5214(91)90012-J) Copyright © 1991 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 3 Muscle weight (grams) before ischemia and after 5 hours of ischemia and 48 hours of reperfusion in vivo. Although muscle weight increased in both groups after 48 hours of reperfusion, (p = 0.007, controls and p = 0.022, modified reperfusion, paired t test), no difference was found between groups (p = 0.23, paired t test). Journal of Vascular Surgery 1991 13, 58-68DOI: (10.1016/0741-5214(91)90012-J) Copyright © 1991 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 4 Muscle blood flow (ml/min/100 gm). PI, Preischemia; ISCH, ischemic interval. Although blood flow was higher in controls during the modified reperfusion phase, this difference was not significant (RM-ANOVA, p = 0.15). However, after return to unaltered arterial inflow, blood flow was transiently higher in the modified reperfusion group than in controls (RM-ANOVA, p = 0.0025). Journal of Vascular Surgery 1991 13, 58-68DOI: (10.1016/0741-5214(91)90012-J) Copyright © 1991 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 5 Tissue myeloperoxidase activity (units/mg tissue protein). PI, Preischemia; EI, end ischemia. Myeloperoxidase activity increased in both groups during reperfusion (p < 0.01), but there was no difference in myeloperoxidase activity between groups at any time point (RM-ANOVA, p = 0.33). Journal of Vascular Surgery 1991 13, 58-68DOI: (10.1016/0741-5214(91)90012-J) Copyright © 1991 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions