Insulin-like growth factor-II (IGF-II), IGF-binding protein-3 (IGFBP-3), and IGFBP-4 in follicular fluid are associated with oocyte maturation and embryo.

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Insulin-like growth factor-II (IGF-II), IGF-binding protein-3 (IGFBP-3), and IGFBP-4 in follicular fluid are associated with oocyte maturation and embryo development Tzu-Hao Wang, M.D., Ph.D., Chia-Lin Chang, M.D., Hsien-Ming Wu, M.D., Ya-Ming Chiu, M.Sc., Chun-Kai Chen, M.D., Hsin-Shih Wang, M.D., Ph.D. Fertility and Sterility Volume 86, Issue 5, Pages 1392-1401 (November 2006) DOI: 10.1016/j.fertnstert.2006.03.064 Copyright © 2006 American Society for Reproductive Medicine Terms and Conditions

FIGURE 1 The correlation between embryo score on day 3 (72 hours after oocyte retrieval) and levels of IGFs and IGFBPs in follicular fluid (n = 120): (A) IGF-II, (B) IGFBP-3, (C) IGFBP-4, and (D) PAPP-A. d.f. = degree of freedom. Wang. IGFs/IGFBPs and embryo development. Fertil Steril 2006. Fertility and Sterility 2006 86, 1392-1401DOI: (10.1016/j.fertnstert.2006.03.064) Copyright © 2006 American Society for Reproductive Medicine Terms and Conditions

FIGURE 2 The relationship between FF levels of (A) IGF-II and IGFBP-4, and (B) PAPP-A and IGFBP-4, analyzed by linear regression (n = 120). d.f. = degree of freedom. Wang. IGFs/IGFBPs and embryo development. Fertil Steril 2006. Fertility and Sterility 2006 86, 1392-1401DOI: (10.1016/j.fertnstert.2006.03.064) Copyright © 2006 American Society for Reproductive Medicine Terms and Conditions

FIGURE 3 Western blot analysis of pooled FF collected from follicles where oocytes were fertilized and developed into embryos using anti-IGFBP-4 (left) and anti-β-actin (right) antibodies. Lane 1, embryo score on day 2 (48 hours after oocyte retrieval) ≥8, representing good embryo development; lane 2, embryo score on day 2 ≤2, indicating an arrest of embryo development. Shown herein is a representative figure from three independent experiments with similar results. Wang. IGFs/IGFBPs and embryo development. Fertil Steril 2006. Fertility and Sterility 2006 86, 1392-1401DOI: (10.1016/j.fertnstert.2006.03.064) Copyright © 2006 American Society for Reproductive Medicine Terms and Conditions

FIGURE 4 Stimulation of P secretion from pooled granulosa cells by in vitro treatment with recombinant IGF-II, IGFBP-3, IGFBP-4, or indicated combinations for 24 hours. Data shown are means ± SD from three independent experiments. Progesterone secretion in each treatment is normalized with the cell number. Abbreviations: II = IGF-II, 3 = IGFBP-3, 4 = IGFBP-4. *P=.013. Wang. IGFs/IGFBPs and embryo development. Fertil Steril 2006. Fertility and Sterility 2006 86, 1392-1401DOI: (10.1016/j.fertnstert.2006.03.064) Copyright © 2006 American Society for Reproductive Medicine Terms and Conditions

FIGURE 5 The effect of the FF levels of IGFs (IGF-I and IGF-II), IGFBPs (IGFBP-1, IGFBP-3, and IGFBP-4), and PAPP-A on the outcomes of oocyte fertilization and subsequent embryo development. Wang. IGFs/IGFBPs and embryo development. Fertil Steril 2006. Fertility and Sterility 2006 86, 1392-1401DOI: (10.1016/j.fertnstert.2006.03.064) Copyright © 2006 American Society for Reproductive Medicine Terms and Conditions