Nitric oxide in acute renal failure: NOS versus NOS

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Presentation transcript:

Nitric oxide in acute renal failure: NOS versus NOS Michael S. Goligorsky, Sergey V. Brodsky, Eisei Noiri Kidney International Volume 61, Issue 3, Pages 855-861 (March 2002) DOI: 10.1046/j.1523-1755.2002.00233.x Copyright © 2002 International Society of Nephrology Terms and Conditions

Figure 1 Cellular effects of nitric oxide (NO) depend on its concentration, site of release and duration of action. Abbreviations are: NOS, nitric oxide synthase; ROI, reactive oxygen intermediates; GC, guanylate cyclase. Kidney International 2002 61, 855-861DOI: (10.1046/j.1523-1755.2002.00233.x) Copyright © 2002 International Society of Nephrology Terms and Conditions

Figure 2 Evolution of our understanding of the involvement of NO and sites of its generation on renal injury. (A) Effects limited to the isolated epithelial cells. (B) The role of peroxynitrite and its potential sources in epithelial cell injury. (C) Involvement of eNOS and NO bioavailability in the subsequent development of injury to the proximal epithelial cells. Abbreviations are: NO, nitric oxide, iNOS, inducible nitric oxide synthase; eNOS, endothelial nitric oxide synthase; L-NAME, N-nitro-l-arginine methyl ester; AS-ODN, antisense oligodeoxynucleotide; MPO, myeloperoxidase. Kidney International 2002 61, 855-861DOI: (10.1046/j.1523-1755.2002.00233.x) Copyright © 2002 International Society of Nephrology Terms and Conditions

Figure 3 Schematic representation of endothelial cell transplantation into the ischemic kidney (left) resulting in the improved renal function (right). Kidney International 2002 61, 855-861DOI: (10.1046/j.1523-1755.2002.00233.x) Copyright © 2002 International Society of Nephrology Terms and Conditions

Kidney International 2002 61, 855-861DOI: (10. 1046/j. 1523-1755. 2002 Kidney International 2002 61, 855-861DOI: (10.1046/j.1523-1755.2002.00233.x) Copyright © 2002 International Society of Nephrology Terms and Conditions