Vivian G. Cheung, Alan Bruzel, Joshua T

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Presentation transcript:

Monozygotic Twins Reveal Germline Contribution to Allelic Expression Differences Vivian G. Cheung, Alan Bruzel, Joshua T. Burdick, Michael Morley, James L. Devlin, Richard S. Spielman The American Journal of Human Genetics Volume 82, Issue 6, Pages 1357-1360 (June 2008) DOI: 10.1016/j.ajhg.2008.05.003 Copyright © 2008 The American Society of Human Genetics Terms and Conditions

Figure 1 Differential Allelic Expression Is Extensive and Influenced by Genetic Variation (A) Allelic expression ratio of 285 exonic SNPs measured in five or more unrelated individuals (colored dots) heterozygous at those sites. SNPs are ordered left to right by mean expression ratio, a/(a+b). (B–D) Allelic expression ratios for selected SNPs in heterozygous MZ twin pairs (identified as in Table S2); twins have highly similar patterns of DAE. (B) Similar measurements were obtained from the two SNPs in STOX1. (C) Expression of the B allele is higher in all individuals studied [mean of a/(a+b) = 0.32 in 31 unrelated individuals]. (D) Twins are highly similar even when there is little evidence of DAE. The American Journal of Human Genetics 2008 82, 1357-1360DOI: (10.1016/j.ajhg.2008.05.003) Copyright © 2008 The American Society of Human Genetics Terms and Conditions