Prevalence of inherited blood disorders and associations with malaria and anemia in Malawian children by Patrick T. McGann, Anne M. Williams, Graham Ellis,

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Prevalence of inherited blood disorders and associations with malaria and anemia in Malawian children by Patrick T. McGann, Anne M. Williams, Graham Ellis, Kathryn E. McElhinney, Laurel Romano, Julia Woodall, Thad A. Howard, Gerald Tegha, Robert Krysiak, R. Murray Lark, E. Louise Ander, Carine Mapango, Kenneth I. Ataga, Satish Gopal, Nigel S. Key, Russell E. Ware, and Parminder S. Suchdev BloodAdv Volume 2(21):3035-3044 November 13, 2018 ©2018 by American Society of Hematology

Patrick T. McGann et al. Blood Adv 2018;2:3035-3044 ©2018 by American Society of Hematology

Molecular determination of sickle cell, α-thalassemia, and G6PD status. Molecular determination of sickle cell, α-thalassemia, and G6PD status. Each panel represents example allelic discrimination (A,C) or probe amplification (B) plots for the reverse transcriptase-PCR assays used to determine each blood disorder. (A) Molecular determination of the presence of absence of the HbS mutation. (B) Probe amplification plots by α-globin genotype, demonstrating later probe amplification with each α-globin gene deletion. (C) Allelic discrimination plot to determine G6PD A vs B isoforms, the presence or absence of the A− isoform, and a confirmatory sex assay to identify male and female samples. Patrick T. McGann et al. Blood Adv 2018;2:3035-3044 ©2018 by American Society of Hematology

Geospatial distribution of HbS in Malawi. Geospatial distribution of HbS in Malawi. This map illustrates the differences in the geospatial distribution of HbS, with areas in the Northeast and West noted to have a higher prevalence of HbS than other areas of Malawi. Patrick T. McGann et al. Blood Adv 2018;2:3035-3044 ©2018 by American Society of Hematology