Mostafa N. El-Sanadiki, MB, MS, K. Simon Cross, MB, John J

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Presentation transcript:

Normal endothelial function and decreased vasoreactivity of experimental arterial grafts Mostafa N. El-Sanadiki, MB, MS, K.Simon Cross, MB, John J. Murray, MD, PhD,*, Eileen M. Mikat, PhD, Richard L. McCann, MD, Per- Otto Hagen, PhD Journal of Vascular Surgery Volume 9, Issue 1, Pages 98-106 (January 1989) DOI: 10.1016/0741-5214(89)90224-3 Copyright © 1989 Society for Vascular Surgery and the North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

Fig. 1 Dose-response curves of norepinephrine for control arteries (n = 10) and arterial grafts at 4 weeks (n = 10). Each point represents mean ± standard error. The ED50 value for arterial grafts was shifted significantly to the right compared with control arteries (p < 0.005). Journal of Vascular Surgery 1989 9, 98-106DOI: (10.1016/0741-5214(89)90224-3) Copyright © 1989 Society for Vascular Surgery and the North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

Fig. 2 Dose-response curves of histamine for control arteries (n = 10) and arterial grafts at 4 weeks (n = 10). Each point represents mean ± standard error. The ED50 value for arterial grafts was again shifted significantly to the right (p < 0.005). Journal of Vascular Surgery 1989 9, 98-106DOI: (10.1016/0741-5214(89)90224-3) Copyright © 1989 Society for Vascular Surgery and the North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

Fig. 3 Dose-response curves of serotonin for control arteries (n = 10) and arterial grafts at 4 weeks (n = 10). Each point represents mean ± standard error. There was no difference between the ED50 values for control arteries and arterial grafts (p = NS). Journal of Vascular Surgery 1989 9, 98-106DOI: (10.1016/0741-5214(89)90224-3) Copyright © 1989 Society for Vascular Surgery and the North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

Fig. 4 Polygraph tracings of representative control artery and arterial graft demonstrate endothelium-dependent relaxation response to acetylcholine (Ach). Acetylcholine (5 × 10−6 mol/L) was added to both rings, which were precontracted with norepinephrine (NE) (ED50). Journal of Vascular Surgery 1989 9, 98-106DOI: (10.1016/0741-5214(89)90224-3) Copyright © 1989 Society for Vascular Surgery and the North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

Fig. 5 Dose-response curves of acetylcholine for rings precontracted with norepinephrine of control arteries (n = 10) and arterial grafts (n = 10) at 4 weeks. Each point represents mean ± standard error. Journal of Vascular Surgery 1989 9, 98-106DOI: (10.1016/0741-5214(89)90224-3) Copyright © 1989 Society for Vascular Surgery and the North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

Fig. 6 Maximal relaxation to acetylcholine (5 × 10−6 mol/L) in rings precontracted with norepinephrine of control arteries (n = 9) and arterial grafts (n = 9). Data are expressed as percentage of relaxation (mean ± SEM). Journal of Vascular Surgery 1989 9, 98-106DOI: (10.1016/0741-5214(89)90224-3) Copyright © 1989 Society for Vascular Surgery and the North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

Fig. 7 A, Scanning electron photomicrograph of luminal surface of control artery shows uniform, flat endothelial cells with microvillous projections that are most prominent at cell junctions. (Original magnification × 3000.) B, Scanning electron photomicrograph of luminal surface of arterial graft shows large cells with endothelial-like microvillous projections most prominent at cell junctions. (Original magnification × 3000.) Journal of Vascular Surgery 1989 9, 98-106DOI: (10.1016/0741-5214(89)90224-3) Copyright © 1989 Society for Vascular Surgery and the North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

Fig. 8 A, Electron photomicrograph of control artery wall shows endothelial cell (ENDO) with nucleus (N) and pinocytotic vesicles (arrowheads) lining lumen. Arrow indicates endothelial cell junction. Basement membrane (BM) is clearly shown overlying internal elastic lamina (E). Collagen fibrils (COL) and smooth muscle cells (SMC) are shown in media. (Original magnification × 8000.) B, Electron photomicrograph of grafted artery shows intimal cell (IC) with typical endothelial cell junction (two arrows at right) and myofilaments with fusiform densities (arrowheads) at cell periphery. These cells have abundant rough endoplasmic reticulum (three arrows at left). Smooth muscle cells (SMC) are present in neointima. (Original magnification × 8000.) Journal of Vascular Surgery 1989 9, 98-106DOI: (10.1016/0741-5214(89)90224-3) Copyright © 1989 Society for Vascular Surgery and the North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions