Effect of co-trimoxazole on mortality in HIV-exposed but uninfected children in Botswana (the Mpepu Study): a double-blind, randomised, placebo-controlled trial  Shahin Lockman, MD, Prof Michael Hughes, PhD, Kate Powis, MD, Gbolahan Ajibola, MB, Kara Bennett, MS, Sikhulile Moyo, MSc, Erik van Widenfelt, BA, Jean Leidner, MS, Prof Kenneth McIntosh, MD, Loeto Mazhani, MD, Joseph Makhema, FRCP, Prof Max Essex, PhD, Dr Roger Shapiro, MD  The Lancet Global Health  Volume 5, Issue 5, Pages e491-e500 (May 2017) DOI: 10.1016/S2214-109X(17)30143-2 Copyright © 2017 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY-NC-ND license Terms and Conditions

Figure 1 Trial profile *36 women had twins and one woman had triplets. The Lancet Global Health 2017 5, e491-e500DOI: (10.1016/S2214-109X(17)30143-2) Copyright © 2017 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY-NC-ND license Terms and Conditions

Figure 2 Cumulative proportions of deaths and of the composite endpoint of death, admission to hospital, and grade 3–4 clinical adverse events in children from baseline to the end of the study (A) Deaths. (B) Composite clinical endpoint. The Lancet Global Health 2017 5, e491-e500DOI: (10.1016/S2214-109X(17)30143-2) Copyright © 2017 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY-NC-ND license Terms and Conditions