Therapy for Alopecia Areata in Mice by Stimulating the Hair Cycle with Parathyroid Hormone Agonists Linked to a Collagen-Binding Domain Ranjitha Katikaneni,

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Therapy for Alopecia Areata in Mice by Stimulating the Hair Cycle with Parathyroid Hormone Agonists Linked to a Collagen-Binding Domain Ranjitha Katikaneni, Andrew W. Seymour, Rohan Gulati, Tulasi Ponnapakkam, Robert C. Gensure Journal of Investigative Dermatology Symposium Proceedings Volume 17, Issue 2, Pages 13-15 (November 2015) DOI: 10.1038/jidsymp.2015.32 Copyright © 2015 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 1 Gross and histological appearance of representative C3H/HeJ-engrafted mice after administration of parathyroid hormone (PTH)-collagen-binding domainCBD or vehicle control. Shown are the photographs of the dorsal surface of the mouse, hematoxylin and eosin staining (H&E) staining of full-thickness skin sections, immunohistochemistry for CD8+ cells in skin, and immunohistochemistry for beta-catenin in skin for a vehicle control animal with no hair loss (1), a vehicle control animal with significant hair loss (2), and a PTH-CBD treated animal with no hair loss (3). In immunohistochemistry analyses, areas of antibody binding appear as brown staining. Journal of Investigative Dermatology Symposium Proceedings 2015 17, 13-15DOI: (10.1038/jidsymp.2015.32) Copyright © 2015 The Society for Investigative Dermatology, Inc Terms and Conditions