Fluctuation of blood and skin plasmacytoid dendritic cells in drug-induced hypersensitivity syndrome Kazunari Sugita, MD, PhD, Mikiko Tohyama, MD, PhD,

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Presentation transcript:

Fluctuation of blood and skin plasmacytoid dendritic cells in drug-induced hypersensitivity syndrome Kazunari Sugita, MD, PhD, Mikiko Tohyama, MD, PhD, Hideaki Watanabe, MD, PhD, Atsushi Otsuka, MD, PhD, Saeko Nakajima, MD, Masafumi Iijima, MD, PhD, Koji Hashimoto, MD, PhD, Yoshiki Tokura, MD, PhD, Yoshiki Miyachi, MD, PhD, Kenji Kabashima, MD, PhD Journal of Allergy and Clinical Immunology Volume 126, Issue 2, Pages 408-410 (August 2010) DOI: 10.1016/j.jaci.2010.06.004 Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 pDC distribution in the blood and in the skin. A and B, Fluorescence-activated cell sorting plots of PBMCs in a healthy donor and a patient (case 1) with DIHS 2, 16, and 72 days after the onset (A). The percentages (upper panel) and the numbers (lower panel) of lineage-(Lin−) CD123+ pDCs in healthy donors, patients with MPE, and patients with DIHS at viral reactivation and at other indicated time points. C, Immunohistochemistry of the skin from a patient with DIHS. Arrowheads indicate pDCs. Skin materials were obtained around the peak of illness. D, Numbers of pDCs in the skin of healthy donors, patients with MPE, and patients with DIHS per high power fields (HPF). Data are presented as means ± SDs. ∗P < .05 (Student t test). PE, Phycoerythrin. Journal of Allergy and Clinical Immunology 2010 126, 408-410DOI: (10.1016/j.jaci.2010.06.004) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions