Histological Subtypes of Lung Adenocarcinoma Have Differential 18F- Fluorodeoxyglucose Uptakes on the Positron Emission Tomography/Computed Tomography.

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Histological Subtypes of Lung Adenocarcinoma Have Differential 18F- Fluorodeoxyglucose Uptakes on the Positron Emission Tomography/Computed Tomography Scan Chao-Hua Chiu, MD, Yi-Chen Yeh, MD, Ko-Han Lin, MD, Yu-Chun Wu, MD, Yu-Chin Lee, MD, Teh-Ying Chou, MD, PhD, Chun-Ming Tsai, MD Journal of Thoracic Oncology Volume 6, Issue 10, Pages 1697-1703 (October 2011) DOI: 10.1097/JTO.0b013e318226b677 Copyright © 2011 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 1 SUVmax in different subtypes of lung adenocarcinomas categorized according to the predominant histological growth pattern. Solid predominant adenocarcinoma has higher SUVmax than other subtypes (A), and there is a correlation between the percentage of solid growth pattern and SUVmax (B). *p less than 0.001. SUVmax, maximal standardized uptake value. Journal of Thoracic Oncology 2011 6, 1697-1703DOI: (10.1097/JTO.0b013e318226b677) Copyright © 2011 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 2 SUVmax in TRU-type and non-TRU-type lung adenocarcinomas. TRU-type adenocarcinoma has significantly lower SUVmax than the non-TRU type in all patients (A) and also in the subgroup, excluding those with a solid growth pattern (B). SUVmax, maximal standardized uptake value; TRU, terminal respiratory unit. Journal of Thoracic Oncology 2011 6, 1697-1703DOI: (10.1097/JTO.0b013e318226b677) Copyright © 2011 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 3 SUVmax in lung adenocarcinomas categorized according to the GLUT-1 immunohistochemical staining intensity (p < 0.001). SUVmax, maximal standardized uptake value; GLUT, glucose transporter type 1. Journal of Thoracic Oncology 2011 6, 1697-1703DOI: (10.1097/JTO.0b013e318226b677) Copyright © 2011 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 4 A representative case of lung adenocarcinoma with mixed TRU (T) and non-TRU (NT) morphology (A; HE stain, 20×), which is apparently highlighted by the immunohistochemical staining of GLUT-1 (B). The magnified view of the right field in panel A shows cancer cells with characteristic TRU morphology (C; HE stain, 200×) and the GLUT-1 staining is negative (D). The magnified view of the left field in panel A shows cancer cells with characteristic non-TRU morphology (E; HE stain, 200×), and the GLUT-1 staining is strongly positive (F). TRU, terminal respiratory unit; HE, hematoxylin and eosin; GLUT, glucose transporter type 1. Journal of Thoracic Oncology 2011 6, 1697-1703DOI: (10.1097/JTO.0b013e318226b677) Copyright © 2011 International Association for the Study of Lung Cancer Terms and Conditions