Flying Under the Radar: Immune Evasion by Group B Streptococcus

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Flying Under the Radar: Immune Evasion by Group B Streptococcus Adelle P. McFarland, Joshua J. Woodward Cell Host & Microbe Volume 20, Issue 1, Pages 4-6 (July 2016) DOI: 10.1016/j.chom.2016.06.015 Copyright © 2016 Elsevier Inc. Terms and Conditions

Figure 1 Degradation of c-di-AMP by Group B Streptococcus Modulates Immune Responses Degradation of extracellular c-di-AMP (upper right panel) by CdnP and NudP leads to the production of adenosine, which may act as an immunosuppressive agent by engaging G protein-coupled adenosine receptors on immune cells. Degradation of DNA scaffolds by the nuclease NucA allows GBS to evade killing by neutrophil extracellular traps (NETs). Degradation of c-di-AMP by CdnP limits STING activation (lower left and right panels); however, bacterial DNA sensed by cGAS still promotes STING activation via production of 2′3′-cGAMP. Cell Host & Microbe 2016 20, 4-6DOI: (10.1016/j.chom.2016.06.015) Copyright © 2016 Elsevier Inc. Terms and Conditions