Molecular Neuroscience in the 21st Century: A Personal Perspective

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Molecular Neuroscience in the 21st Century: A Personal Perspective Thomas C. Südhof Neuron Volume 96, Issue 3, Pages 536-541 (November 2017) DOI: 10.1016/j.neuron.2017.10.005 Copyright © 2017 Elsevier Inc. Terms and Conditions

Figure 1 Illustration of Neuronal Shape and Spines: An Exemplary Pyramidal Neuron from the CA1 Region of the Hippocampus with Spine-Studded Dendritic Extensions (A) Top: a CA1-region pyramidal neuron was patched in hippocampal slices from a mouse that had been sparsely infected with a lentivirus encoding EGFP, and was filled with biocytin via the patch pipette (image shows a section stained for biocytin [red] and DAPI to label nuclei [blue]). Bottom: expansion of the dendritic field boxed in the neuronal overview image above to illustrate the dense decoration of dendrites with spines. (B) Three-dimensional reconstruction of the pyramidal neuron and its dendritic segment shown in (A). In the bottom panel, spine shapes were categorized and color-coded (blue, mushroom; green, thin; pink, stubby). Images courtesy of Dr. Richard Sando. Neuron 2017 96, 536-541DOI: (10.1016/j.neuron.2017.10.005) Copyright © 2017 Elsevier Inc. Terms and Conditions