Induction of systemic immunologic tolerance to β-lactoglobulin by oral administration of a whey protein hydrolysate Rodolphe Fritsché, PhD, Jean Jacques.

Slides:

Advertisements

Similar presentations

A novel wheat gliadin as a cause of exercise-induced anaphylaxis

Advertisements

Yvan Boutin, PhD, Jacques Hébert, MD

Biologic allergen assay for in vivo test allergens with an in vitro model of the murine type I reaction Andreas Hoffmann, VMD, Stefan Vieths, PhD, Dieter.

In vitro lymphocyte proliferation with milk and a casein–whey protein hydrolyzed formula in children with cow's milk allergy Philippe A. Eigenmann, MD,

Induction of systemic immunologic tolerance to β-lactoglobulin by oral administration of a whey protein hydrolysate Rodolphe Fritsché, PhD, Jean Jacques.

Kuan-Wei Chen, PhD, Katharina Blatt, MSc, Wayne R

Cord blood mononuclear cells and milk-specific T-cell clones are tools to evaluate the residual immunogenicity of hydrolyzed milk formulas Zsolt Szépfalusi,

Allergy to latex, avocado pear, and banana: Evidence for a 30 kd antigen in immunoblotting François Lavaud, MD, Alain Prevost, MD, Claude Cossart, MD,

Heat-killed Lactobacillus plantarum L-137 suppresses naturally fed antigen–specific IgE production by stimulation of IL-12 production in mice Shinji.

Wheat α-amylase inhibitor: A second route of allergic sensitization

Designing hypoallergenic derivatives for allergy treatment by means of in silico mutation and screening Theresa Thalhamer, PhD, Heidi Dobias, MSc, Tatjana.

Anaphylaxis to wheat isolates: Immunochemical study of a case proved by means of double-blind, placebo-controlled food challenge Virginie Leduc, PhD,

Development and characterization of a recombinant, hypoallergenic, peptide-based vaccine for grass pollen allergy Margarete Focke-Tejkl, PhD, Milena.

Blocking antibodies induced by immunization with a hypoallergenic parvalbumin mutant reduce allergic symptoms in a mouse model of fish allergy Raphaela.

Skin test diagnosis of grass pollen allergy with a recombinant hybrid molecule Carine Metz-Favre, MD, Birgit Linhart, PhD, Margarete Focke-Tejkl, PhD,

Oral immunotherapy induces IgG antibodies that act through FcγRIIb to suppress IgE- mediated hypersensitivity Oliver T. Burton, PhD, Stephanie L. Logsdon,

Expression of IL-4 receptor α on smooth muscle cells is not necessary for development of experimental allergic asthma Frank Kirstein, PhD, William G.C.

In vitro lymphocyte proliferation with milk and a casein–whey protein hydrolyzed formula in children with cow's milk allergy Philippe A. Eigenmann, MD,

Elisabeth Roesler, MSc, Richard Weiss, PhD, Esther E

A novel wheat gliadin as a cause of exercise-induced anaphylaxis

A randomized, double-blind, placebo-controlled study of omalizumab combined with oral immunotherapy for the treatment of cow's milk allergy Robert A.

Rush immunotherapy results in allergen-specific alterations in lymphocyte function and interferon-γ production in CD4+ T cells Gideon Lack, MD, Harold.

Rosaura Casas, MSc, Malin F

Badrul A. Chowdhury, MD, PhD

In vivo allergenic activity of a hypoallergenic mutant of the major fish allergen Cyp c 1 evaluated by means of skin testing Nikolaos Douladiris, MD,

Forkhead box protein 3 demethylation is associated with tolerance induction in peanut- induced intestinal allergy Meiqin Wang, MD, PhD, Ivana V. Yang,

Induction of IgE antibodies in mice and rhesus monkeys with recombinant birch pollen allergens: Different allergenicity of Bet v 1 and Bet v 2 Susanne.

Oliver T. Burton, PhD, Jaciel M. Tamayo, PhD, Amanda J

Allergy to eggs from duck and goose without sensitization to hen egg proteins Belén Añíbarro, MD, F.Javier Seoane, MD, Concepción Vila, MD, Manuel Lombardero,

Anti-HLA antibody binding to HLA class I molecules induces proliferation of airway epithelial cells: A potential mechanism for bronchiolitis obliterans.

Common allergens in avian meats

Paul Van Durme, MDa, Jan L. Ceuppens, MD, PhDa,b, Pascal Cadot, PhDb

Cross-reactivity between the major allergen from olive pollen and unrelated glycoproteins: Evidence of an epitope in the glycan moiety of the allergen

Affinity purification of latex antigens

Determinant analysis of IgE and IgG4 antibodies and T cells specific for bovine αs1- casein from the same patients allergic to cow's milk: Existence of.

Protein unfolding strongly modulates the allergenicity and immunogenicity of Pru p 3, the major peach allergen Masako Toda, PhD, Gerald Reese, PhD, Gabriele.

Influence of refining steps on trace allergenic protein content in sunflower oil Nedjma Zitouni, PhD, Younes Errahali, MS, Maurice Metche, PhD, Gisèle.

Anna-Riitta Hänninen, BSc a, Jari H

A hypoallergenic variant of Der p 1 as a candidate for mite allergy vaccines David Walgraffe, PhD, Christel Mattéotti, PhD, Mohamed el Bakkoury, PhD,

BDA20, a major bovine dander allergen characterized at the sequence level, is Bos d 2 Jaakko Rautianinen, MSc, Marho Rytkönen, MSc, Tuomas Virtanen, MD,

Immunostimulatory potential of β-lactoglobulin preparations

IFN-τ inhibits IgE production in a murine model of allergy and in an IgE-producing human myeloma cell line Mustafa G. Mujtaba, PhDa, Lorelie Villarete,

Systemic allergic reaction to coconut (Cocos nucifera) in 2 subjects with hypersensitivity to tree nut and demonstration of cross-reactivity to legumin-like.

Kuan-Wei Chen, PhD, Katharina Blatt, MSc, Wayne R

Allergy to cooked white potatoes in infants and young children: A cause of severe, chronic allergic disease Liliane F.A. De Swert, MD, Pascal Cadot,

IL-12 affects Dermatophagoides farinae–induced IL-4 production by T cells from pediatric patients with mite-sensitive asthma Takeshi Noma, MD, PhD, Izumi.

Ganglioside GQ1b enhances Ig production by human PBMCs

Erik Melén, BSc, Anna Pomés, PhD, Lisa D. Vailes, MS, L

Dietary medium-chain triglycerides promote oral allergic sensitization and orally induced anaphylaxis to peanut protein in mice Jianing Li, MS, Yu Wang,

TH1-promoting DNA immunization against allergens modulates the ratio of IgG1/IgG2a but does not affect the anaphylactic potential of IgG1 antibodies

Antigen-specific and nonspecific determinants of cytokine production during topical sensitization of mice to chemical allergens Artin Moussavi, PhDa,

Occupational allergy caused by urticating hair of Brazilian spider

Anna Nowak-Wegrzyn, MD, Gail G

Beer anaphylaxis Journal of Allergy and Clinical Immunology

B-cell epitopes as a screening instrument for persistent cow's milk allergy Kirsi-Marjut Järvinen, MD, PhD, Kirsten Beyer, MD, Leticia Vila, MD, Pantipa.

A hypoallergenic cat vaccine based on Fel d 1–derived peptides fused to hepatitis B PreS Katarzyna Niespodziana, MSc, Margarete Focke-Tejkl, PhD, Birgit.

Lama A. Youssef, B Pharm, Bridget S. Wilson, PhD, Janet M. Oliver, PhD

Continued expression of anti-soy protein antibodies in rats bred on a soy protein–free diet for one generation: The importance of dietary control in oral.

Harald Renz, MD, Chaya Brodie, PhD, Katherine Bradley, BS, Donald Y. M

Qianli Zhuang, MD, PhD, Bruce Mazer, MD

In vivo effects of glucocorticoids on IgE production

Adverse reaction to lupine-fortified pasta

Exposure to cow’s milk during the first 3 months of life is associated with increased levels of IgG subclass antibodies to β-lactoglobulin to 8 years

Lymphocytes in Peyer patches regulate clinical tolerance in a murine model of food allergy Christophe P. Frossard, MS, Laurence Tropia, Conrad Hauser,

Oral administration of a dominant T-cell determinant peptide inhibits allergen-specific TH1 and TH2 cell responses in Cry j 2–primed mice Kazuki Hirahara,

Ovalbumin-specific IgE modulates ovalbumin-specific T-cell response after repetitive oral antigen administration Nemuko Omata, MD, Yusei Ohshima, MD,

Philippe A. Eigenmann, MD,a, A. Wesley Burks, MD,b, Gary A

Natural history of cow’s milk allergy

23. Clinical laboratory assessment of IgE-dependent hypersensitivity

Molecular cloning of a major Alternaria alternata allergen, rAlt a 2

Presentation transcript:

Induction of systemic immunologic tolerance to β-lactoglobulin by oral administration of a whey protein hydrolysate Rodolphe Fritsché, PhD, Jean Jacques Pahud, PhD, Sophie Pecquet, Andrea Pfeifer, PhD Journal of Allergy and Clinical Immunology Volume 100, Issue 2, Pages 266-273 (August 1997) DOI: 10.1016/S0091-6749(97)70235-5 Copyright © 1997 Mosby, Inc. Terms and Conditions

Fig. 1 Characterization of cow's milk formulas by SDS-PAGE. Lane 1, Molecular weight markers (at left of lane 1 molecular weights are indicated in kilodaltons); lane 2, ALFARE; lane 3, BEBA-HA; lane 4, NAN. All formulas were analyzed at a concentration of 0.8 mg of protein equivalent per 10 ml of solution applied. Journal of Allergy and Clinical Immunology 1997 100, 266-273DOI: (10.1016/S0091-6749(97)70235-5) Copyright © 1997 Mosby, Inc. Terms and Conditions

Fig. 2 Residual βLG-specific allergenicity in cow's milk formulas. This was tested by tritiated serotonin release from rat mast cells sensitized passively with rat IgE anti-βLG antibodies. Dose-dependent release curves obtained by triggering sensitized mast cells with βLG or the three formulas are shown. Journal of Allergy and Clinical Immunology 1997 100, 266-273DOI: (10.1016/S0091-6749(97)70235-5) Copyright © 1997 Mosby, Inc. Terms and Conditions

Fig. 3 Antibody suppression by oral tolerance with cow's milk formulas. ELISA (log5) titers of IgE and IgG anti-βLG or anti-ovalbumin antibodies in sera from rats orally tolerized with NAN, BEBA-HA, ALFARE, or water. Journal of Allergy and Clinical Immunology 1997 100, 266-273DOI: (10.1016/S0091-6749(97)70235-5) Copyright © 1997 Mosby, Inc. Terms and Conditions

Fig. 4 Dose dependency of antibody suppression. ELISA (log5) titers of IgE anti-βLG or anti-ovalbumin antibodies in sera from rats orally tolerized with increasing doses (0 to 120 gm/L) of NAN or BEBA-HA. BLG, β-Lactoglobulin; OVA, ovalbumin. Journal of Allergy and Clinical Immunology 1997 100, 266-273DOI: (10.1016/S0091-6749(97)70235-5) Copyright © 1997 Mosby, Inc. Terms and Conditions

Fig. 5 In vitro suppression of mast cell response. Tritiated serotonin release from mast cells passively sensitized with sera of rats orally tolerized with NAN, BEBA-HA, ALFARE, or water. Triggering was done with βLG (0.01 to 1000 μg/ml). Journal of Allergy and Clinical Immunology 1997 100, 266-273DOI: (10.1016/S0091-6749(97)70235-5) Copyright © 1997 Mosby, Inc. Terms and Conditions

Fig. 6 In vivo suppression of mast cell response. RMCPII release from intestinal mast cells of rats orally tolerized with NAN, BEBA-HA, or water. Serum levels of RMCPII after challenge with whey proteins are shown for three different experiments in which the same protocol was used. Journal of Allergy and Clinical Immunology 1997 100, 266-273DOI: (10.1016/S0091-6749(97)70235-5) Copyright © 1997 Mosby, Inc. Terms and Conditions

Fig. 7 Lymphocyte stimulation determined by tritiated thymidine incorporation. Lymph node lymphocytes from rats pre-fed with NAN, BEBA-HA, or ALFARE or from control rats (group given water only) were stimulated with βLG. Dose-dependent incorporation curves are shown. Journal of Allergy and Clinical Immunology 1997 100, 266-273DOI: (10.1016/S0091-6749(97)70235-5) Copyright © 1997 Mosby, Inc. Terms and Conditions