IFN-α Enhances IL-22 Receptor Expression in Keratinocytes: A Possible Role in the Development of Psoriasis Mikiko Tohyama, Lujun Yang, Yasushi Hanakawa,

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IFN-α Enhances IL-22 Receptor Expression in Keratinocytes: A Possible Role in the Development of Psoriasis Mikiko Tohyama, Lujun Yang, Yasushi Hanakawa, Xiuju Dai, Yuji Shirakata, Koji Sayama Journal of Investigative Dermatology Volume 132, Issue 7, Pages 1933-1935 (July 2012) DOI: 10.1038/jid.2011.468 Copyright © 2012 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 1 Enhancement of IL-22 receptor (IL-22R) expression in keratinocytes by IFN-α. Living skin equivalent was treated with IFN-α for the indicated time and at the indicated concentrations (a–e). mRNA expression of IL-22R (a,b) or other receptors (c) was analyzed and normalized to glyceraldehyde-3-phosphate dehydrogenase control. The results are expressed as the mean±standard deviation. IL-22R protein expression in keratinocytes was analyzed by immunofluorescence staining (d) or by flow cytometry analysis (e). Bar=100μm. Journal of Investigative Dermatology 2012 132, 1933-1935DOI: (10.1038/jid.2011.468) Copyright © 2012 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 2 Enhancement of IL-22 receptor (IL-22R)-induced signal transducer and activator of transcription 3 (STAT3) phosphorylation by IFN-α. Living skin equivalent (LSE) was pretreated with IFN-α for 24hours and then stimulated with IL-22 for 30 and 60minutes (a) or for 60minutes (b). pSTAT3 was analyzed by western blotting (a) or immunofluorescence staining (b). Nuclear staining of pSTAT3 was apparent in the keratinocytes of LSE pretreated with IFN-α (b). Bar=100μm. Percentage of nuclear pSTAT3-positive cells was measured, and the results are expressed as the mean±standard deviation (c). Statistical analysis of the data was evaluated using Student'st-test. Journal of Investigative Dermatology 2012 132, 1933-1935DOI: (10.1038/jid.2011.468) Copyright © 2012 The Society for Investigative Dermatology, Inc Terms and Conditions