LOX Out, Histones: A New Enzyme Is Nipping at Your Tails

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LOX Out, Histones: A New Enzyme Is Nipping at Your Tails Joshua C. Black, Johnathan R. Whetstine Molecular Cell Volume 46, Issue 3, Pages 243-244 (May 2012) DOI: 10.1016/j.molcel.2012.04.023 Copyright © 2012 Elsevier Inc. Terms and Conditions

Figure 1 Enzymes and Mechanisms for Removing Methyl Groups from Histones (A) Methyl modifications can be removed from histones by FAD-dependent demethylation (KDM1), JmjC-dependent demethylation (KDM5), removal of modified tails by clippases (cathepsin L, CathL) or conversion of arginine to citrulline (PADI4). (B) Reaction schemes for removal of methyl groups from lysines. Cit, citrulline; Suc, succinate; αKG, alpha-ketoglutarate; daK, deaminated lysine). (C) Domain organization of lysyl oxidase family members. GI, gene ID. Molecular Cell 2012 46, 243-244DOI: (10.1016/j.molcel.2012.04.023) Copyright © 2012 Elsevier Inc. Terms and Conditions