Metabolic and hemodynamic effects of intravenous glutamate infusion early after coronary operations Rolf Svedjeholm, MD, PhDa, Ingemar Vanhanen, MDa,

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Presentation transcript:

Metabolic and hemodynamic effects of intravenous glutamate infusion early after coronary operations Rolf Svedjeholm, MD, PhDa, Ingemar Vanhanen, MDa, Erik Håkanson, MD, PhDb, P.O. Joachimsson, MD, PhDc, Lennart Jorfeldt, MD, PhDd, Lennart Nilsson, MD, PhDe The Journal of Thoracic and Cardiovascular Surgery Volume 112, Issue 6, Pages 1468-1477 (December 1996) DOI: 10.1016/S0022-5223(96)70005-3 Copyright © 1996 Mosby, Inc. Terms and Conditions

Fig. 1 Change in hemodynamic state from basal state to 60 minutes, expressed as percentages (mean ± SEM) in control (hatched bars) and glutamate (gray bars) groups. CI, Cardiac index; HR, heart rate; MAP, mean arterial pressure; SVRI, systemic vascular resistance index; LVSWI, left ventricular stroke work index. Asterisks indicate statistically significant differences from basal state, with single asterisk representing p < 0.05 and double asterisk representing p < 0.01. The Journal of Thoracic and Cardiovascular Surgery 1996 112, 1468-1477DOI: (10.1016/S0022-5223(96)70005-3) Copyright © 1996 Mosby, Inc. Terms and Conditions

Fig. 2 Myocardial glutamate uptake (μmol/min; bars) and arterial glutamate level (μmol/L; straight line with squares) according to whole blood analyses (mean ± SEM). Asterisks indicate statistically significant differences from basal state, with single asterisk representing p < 0.05 and double asterisk representing p < 0.01. The Journal of Thoracic and Cardiovascular Surgery 1996 112, 1468-1477DOI: (10.1016/S0022-5223(96)70005-3) Copyright © 1996 Mosby, Inc. Terms and Conditions

Fig. 4 Fractional (%) uptake of lactate in glutamate group (mean ± SEM). Asterisks indicate statistically significant differences from basal state, with single asterisk representing p < 0.05 and double asterisk representing p < 0.01. The Journal of Thoracic and Cardiovascular Surgery 1996 112, 1468-1477DOI: (10.1016/S0022-5223(96)70005-3) Copyright © 1996 Mosby, Inc. Terms and Conditions

Fig. 3 Change in myocardial flux of substrates in control (hatched bars) and glutamate (gray bars) groups from the basal state to 60 minutes (mean ± SEM). Glut, Glutamate; Lact, lactate; Ala, alanine; Gluc, glucose; FFA, free fatty acids. Asterisks indicate statistically significant differences from basal state, with single asterisk representing p < 0.05. The Journal of Thoracic and Cardiovascular Surgery 1996 112, 1468-1477DOI: (10.1016/S0022-5223(96)70005-3) Copyright © 1996 Mosby, Inc. Terms and Conditions