Wash-in kinetics for sevoflurane using a disposable delivery system (AnaConDa®) in cardiac surgery patients L.W. Sturesson, A. Johansson, M. Bodelsson,

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Presentation transcript:

Wash-in kinetics for sevoflurane using a disposable delivery system (AnaConDa®) in cardiac surgery patients L.W. Sturesson, A. Johansson, M. Bodelsson, G. Malmkvist British Journal of Anaesthesia Volume 102, Issue 4, Pages 470-476 (April 2009) DOI: 10.1093/bja/aep019 Copyright © 2009 British Journal of Anaesthesia Terms and Conditions

Fig 1 Wash-in kinetics for sevoflurane using a vaporizer or AnaConDa® measured as the tension in arterial blood using gas chromatography. The arterial sevoflurane tension achieved by using the AnaConDa® was lower than that using a vaporizer during the first 5 min. This relationship was reversed after 10 min and from 15 min on the arterial sevoflurane tension was similar. *Statistically significant difference from value using a vaporizer. Two-way repeated measurement anova for factors time and sevoflurane administration device followed by the Holm–Sidak post hoc test when appropriate. Values are mean (sd) were normalized to the value at 30 min (n=8 in each group). British Journal of Anaesthesia 2009 102, 470-476DOI: (10.1093/bja/aep019) Copyright © 2009 British Journal of Anaesthesia Terms and Conditions

Fig 2 Wash-in of sevoflurane using a vaporizer measured as the tension of sevoflurane in arterial blood using gas chromatography, and in the end-tidal, and inspired gas using a conventional anaesthesia gas monitor. The arterial tension of sevoflurane increased and levelled out after 20 min. The sevoflurane tension in inspired gas was significantly higher than in arterial blood at all time points and the end-tidal tension was higher for the first 10 min. Values are mean (sd), n=8. British Journal of Anaesthesia 2009 102, 470-476DOI: (10.1093/bja/aep019) Copyright © 2009 British Journal of Anaesthesia Terms and Conditions

Fig 3 Wash-in of sevoflurane using an AnaConDa® measured the partial tension of sevoflurane in arterial blood using gas chromatography, and in the end-tidal, and inspired gas using a conventional anaesthesia gas monitor. The arterial tension of sevoflurane increased and levelled out after 10 min. The end-tidal sevoflurane tension did not differ significantly from the tension in the arterial blood whereas the apparent sevoflurane tension in inspired gas was significantly lower than in the arterial blood at all time points. Values are mean (sd), n=8. British Journal of Anaesthesia 2009 102, 470-476DOI: (10.1093/bja/aep019) Copyright © 2009 British Journal of Anaesthesia Terms and Conditions

Fig 4 Detailed airway gases time–tension plots with the use of an AnaConDa®. Gas was sampled at the designated port of the device (AnaConDa®) and at a port on the tracheal tube connector (Tube), which during inspiration was 5 cm downstream of the former. CO2 and sevoflurane were analysed simultaneously, and each curve is the mean of five consecutive breaths. The time point of the lowest CO2 tension of each averaged breath is designated time zero, and sevoflurane tensions are plotted at the time points of the corresponding CO2 tensions. British Journal of Anaesthesia 2009 102, 470-476DOI: (10.1093/bja/aep019) Copyright © 2009 British Journal of Anaesthesia Terms and Conditions