Perreault S, et al. Eur J Clin Pharmacol 2009 Jun 16 [Epub]

Flow chart of inclusion and exclusion criteria Exclusion criteria were assessed in the 2 years preceding the index date for the medication and in the 5 years preceding the index date for hospitalizations, diagnosis, or medical procedures Perreault S, et al. Eur J Clin Pharmacol 2009 Jun 16 [Epub]

Characteristics of patients in the cohort starting a new statin treatment in the Quebec RAMQ database in 1999–2004 Perreault S, et al. Eur J Clin Pharmacol 2009 Jun 16 [Epub]

Characteristics of patients at the baseline with respect to the adherence level Perreault S, et al. Eur J Clin Pharmacol 2009 Jun 16 [Epub]

Characteristics of patients and their matched controls having experienced a CAD a P values are related to analyses made to compare cases with controls b At treatment initiation c Statin equivalent in simvastatin dose during follow-up. Simvastatin 20 mg = lovastatin 40 mg = pravastatin 40 mg = fluvastatin 80 mg = atorvastatin 10 mg = rosuvastatin 5 mg d Proportion of days covered (%) e Diagnosis of cerebrovascular disease: (ICD-9 codes 430–438) or medical procedures f Diagnosis of peripheral artery disease: diagnosis (ICD-9 codes 440–447), medical procedure of noncoronary angioplasty, or use of pentoxifylline g Diagnosis of chronic heart failure: (ICD-9 codes: 398.91, 402.01, 402.11, 402.91, 428.0, 428.1, and 428.9) or a prescription of furosemide alone or with digoxin, ACEI, spironolactone, or β-blockers h Diagnosis of other CVD: arrhythmia: diagnosis (ICD-9 code 427), a medical procedure using a pacemaker, or use of drugs for cardiac arrhythmias (amiodarone, digoxin, quinidine, disopyramide, flecainamide, mexiletine, procainamide, propafenone, or sotalol); or valvular heart disease; or use of anticoagulants i ICD-9 or pharmacologic treatment j Proportion of days covered (%) in the year before the index date Perreault S, et al. Eur J Clin Pharmacol 2009 Jun 16 [Epub]

Kaplan-Meier curves of the time to the first CAD event among high and low adherence levels Perreault S, et al. Eur J Clin Pharmacol 2009 Jun 16 [Epub]

Rate ratios (RR) and 95% confidence intervals of coronary artery disease a Statin equivalent in simvastatin dose during follow-up. Simvastatin 20 mg = lovastatin 40 mg = pravastatin 40 mg = fluvastatin 80 mg = atorvastatin 10 mg = rosuvastatin 5 mg b Proportion of days covered (%) c At treatment initiation d Diagnosis of cerebrovascular disease: (ICD-9 codes 430–438) or medical procedures e Diagnosis of peripheral artery disease: diagnosis (ICD-9 codes 440–447), medical procedure of noncoronary angioplasty, or use of pentoxifylline f Diagnosis of chronic heart failure: (ICD-9 codes: 398.91, 402.01, 402.11, 402.91, 428.0, 428.1, and 428.9) or a prescription of furosemide alone or with digoxin, ACEI, spironolactone, or β-blockers g Diagnosis of other CVD: arrhythmia: diagnosis (ICD-9 code 427), a medical procedure using a pacemaker, or use of drugs for cardiac arrhythmias (amiodarone, digoxin, quinidine, disopyramide, flecainamide, mexiletine, procainamide, propafenone, or sotalol); or valvular heart disease; or use of anticoagulants h ICD-9 or pharmacologic treatment i Proportion of days covered (%) in the year before the index date Perreault S, et al. Eur J Clin Pharmacol 2009 Jun 16 [Epub]

Change in RR of CAD after adjustment for unmeasured confounders Perreault S, et al. Eur J Clin Pharmacol 2009 Jun 16 [Epub]