Sugammadex rapidly reverses moderate rocuronium- or vecuronium-induced neuromuscular block during sevoflurane anaesthesia: a dose–response relationship

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Presentation transcript:

Sugammadex rapidly reverses moderate rocuronium- or vecuronium-induced neuromuscular block during sevoflurane anaesthesia: a dose–response relationship F.K. Pühringer, M Gordon, I Demeyer, H.J. Sparr, J Ingimarsson, B Klarin, W van Duijnhoven, M Heeringa British Journal of Anaesthesia Volume 105, Issue 5, Pages 610-619 (November 2010) DOI: 10.1093/bja/aeq226 Copyright © 2010 The Author(s) Terms and Conditions

Fig 1 Patient flow diagram. ASPE, all-subjects-pharmacokinetically evaluable; AST, all-subjects-treated; ITT, intention-to-treat; PP, per-protocol. British Journal of Anaesthesia 2010 105, 610-619DOI: (10.1093/bja/aeq226) Copyright © 2010 The Author(s) Terms and Conditions

Fig 2 Estimated dose–response relationship between recovery of T4/T1 ratio to 0.9 and the dose of sugammadex administered after (a) rocuronium 0.9 mg kg−1 and (b) vecuronium 0.1 mg kg−1, with 95% confidence intervals (CI; PP subjects). British Journal of Anaesthesia 2010 105, 610-619DOI: (10.1093/bja/aeq226) Copyright © 2010 The Author(s) Terms and Conditions

Fig 3 Median total (sum of free and bound) plasma concentration–time profiles of sugammadex administered after (a) rocuronium 0.9 mg kg−1 and (b) vecuronium 0.1 mg kg−1 (all subjects pharmacokinetically evaluable). The inset graphs show dose-normalized concentrations of sugammadex [(µg ml−1)/(mg kg−1)] vs time (min) after sugammadex administration. British Journal of Anaesthesia 2010 105, 610-619DOI: (10.1093/bja/aeq226) Copyright © 2010 The Author(s) Terms and Conditions

Fig 4 Median plasma concentration–time profiles of (a) rocuronium after administration of rocuronium 0.9 mg kg−1 followed by sugammadex 0.5–4.0 mg kg−1 or placebo and (b) vecuronium after administration of vecuronium 0.1 mg kg−1 followed by sugammadex 0.5–4.0 mg kg−1 or placebo (all subjects pharmacokinetically evaluable). The inset graphs show concentrations of rocuronium and vecuronium (ng ml−1) vs time (min) after sugammadex administration. British Journal of Anaesthesia 2010 105, 610-619DOI: (10.1093/bja/aeq226) Copyright © 2010 The Author(s) Terms and Conditions