Postmenopausal dehydroepiandrosterone administration increases free insulin-like growth factor-I and decreases high-density lipoprotein: a six-month trial

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Postmenopausal dehydroepiandrosterone administration increases free insulin-like growth factor-I and decreases high-density lipoprotein: a six-month trial Peter R. Casson, Nanette Santoro, Karen Elkind-Hirsch, Sandra A. Carson, Peter J. Hornsby, Guy Abraham, John E. Buster Fertility and Sterility Volume 70, Issue 1, Pages 107-110 (July 1998) DOI: 10.1016/S0015-0282(98)00121-6

Figure 1 Monthly serum levels of DHEA, DHEAS, and T after daily administration of 25 mg of oral micronized DHEA (n = 6 and n = 7 in placebo and DHEA arms, respectively). These values are nadir levels at 23 hours after the dose. DHEAS, DHEA, and T all decreased toward placebo values by 6 months, indicating a time-dependent reduction in bioavailability (dose attenuation). Fertility and Sterility 1998 70, 107-110DOI: (10.1016/S0015-0282(98)00121-6)

Figure 2 The ratio of insulin-like growth factor-I (IGF-I) to IGF binding protein-3 (IGFBP-3) at 3 and 6 months (n = 6 and n = 7 in placebo and DHEA arms, respectively). This ratio, thought to approximate the free IGF-I effect (12), was elevated with DHEA treatment compared with placebo. With dose attenuation, the effect was lost at 6 months. Fertility and Sterility 1998 70, 107-110DOI: (10.1016/S0015-0282(98)00121-6)

Figure 3 Fasting serum high-density lipoprotein (HDL) and apolipoprotein A1 (APOA1) levels after 6 months of treatment with DHEA or placebo. Even with the previously noted dose attenuation of DHEA, HDL and apolipoprotein A1 levels were decreased by 6 months compared with placebo (n = 6 and n = 7 in placebo and DHEA arms, respectively). Fertility and Sterility 1998 70, 107-110DOI: (10.1016/S0015-0282(98)00121-6)