The Hormonal Control of Food Intake

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The Hormonal Control of Food Intake Anthony P. Coll, I. Sadaf Farooqi, Stephen O'Rahilly Cell Volume 129, Issue 2, Pages 251-262 (April 2007) DOI: 10.1016/j.cell.2007.04.001 Copyright © 2007 Elsevier Inc. Terms and Conditions

Figure 1 Control of Food Intake by the Hypothalamic Leptin-Melanocortin Pathway The hypothalamus receives and integrates neural, metabolic, and hormonal signals to regulate energy homeostasis. In particular, the adipocyte-derived hormone leptin and the melanocortin pathway have a critical role in the control of food intake. AgRP, Agouti-related protein; Arc, arcuate nucleus; MC4R, melanocortin 4 receptor; POMC, pro-opiomelanocortin; PVN, paraventricular nucleus. Cell 2007 129, 251-262DOI: (10.1016/j.cell.2007.04.001) Copyright © 2007 Elsevier Inc. Terms and Conditions

Figure 2 Hormones from the Gut and Endocrine Organs Affect Food Intake Hormonal signals derived from the gut and classical endocrine organs, such as the pancreas, thyroid, and adrenal glands act in synergy to effect changes in feeding behavior. CCK, cholecystokinin; OXM, oxyntomodulin; GLP-1, glucagon-like peptide 1; PYY3–36, peptide YY3–36. Cell 2007 129, 251-262DOI: (10.1016/j.cell.2007.04.001) Copyright © 2007 Elsevier Inc. Terms and Conditions