The effect of ischemia/reperfusion on adenine nucleotide metabolism and xanthine oxidase production in skeletal muscle Thomas F. Lindsay, MD, Shinta.

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Presentation transcript:

The effect of ischemia/reperfusion on adenine nucleotide metabolism and xanthine oxidase production in skeletal muscle Thomas F. Lindsay, MD, Shinta Liauw, MSc, Alex D. Romaschin, PhD, Paul M. Walker, MD, PhD, FRCS(C) Journal of Vascular Surgery Volume 12, Issue 1, Pages 8-15 (July 1990) DOI: 10.1016/0741-5214(90)90360-M Copyright © 1990 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 1 Creatine phosphate (CP) levels in μmol/gm/dry weight, at preischemia (PI), end ischemia (EI), and at 5 to 45 minutes of reperfusion. Solid dots = 4 hours and open dots = 5 hours of ischemic stress (mean ± SEM, n = 8). Journal of Vascular Surgery 1990 12, 8-15DOI: (10.1016/0741-5214(90)90360-M) Copyright © 1990 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 2 Energy charge potential (ECP) at preischemia (PI), end ischemia (EI), and at 5 to 45 minutes of reperfusion. Solid dots = 4 hours and open dots = 5 hours of ischemic stress (mean ± SEM, n = 8). Journal of Vascular Surgery 1990 12, 8-15DOI: (10.1016/0741-5214(90)90360-M) Copyright © 1990 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 3 The relationship between ATP/ADP ratio and intracellular stores of CP is demonstrated at end ischemia and at 5, 15, 30, 45 minutes of reperfusion (n = 8, r = 0.72, p < 0.05). Journal of Vascular Surgery 1990 12, 8-15DOI: (10.1016/0741-5214(90)90360-M) Copyright © 1990 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions