Enhanced Functions of Electrical Junctions

Slides:

Advertisements

Similar presentations

The Neurobiology of Decision: Consensus and Controversy Joseph W. Kable, Paul W. Glimcher Neuron Volume 63, Issue 6, Pages (September 2009) DOI:

Advertisements

Treating the Developing versus Developed Brain: Translating Preclinical Mouse and Human Studies B.J. Casey, Charles E. Glatt, Francis S. Lee Neuron Volume.

Preference Distributions of Primary Motor Cortex Neurons Reflect Control Solutions Optimized for Limb Biomechanics Timothy P. Lillicrap, Stephen H. Scott.

The Pathobiology of Vascular Dementia Costantino Iadecola Neuron Volume 80, Issue 4, Pages (November 2013) DOI: /j.neuron Copyright.

UvrD Helicase Unwinds DNA One Base Pair at a Time by a Two-Part Power Stroke Jae Young Lee, Wei Yang Cell Volume 127, Issue 7, Pages (December.

Decision Making as a Window on Cognition Michael N. Shadlen, Roozbeh Kiani Neuron Volume 80, Issue 3, Pages (October 2013) DOI: /j.neuron

Contour Saliency in Primary Visual Cortex Wu Li, Valentin Piëch, Charles D. Gilbert Neuron Volume 50, Issue 6, Pages (June 2006) DOI: /j.neuron

GDE2 Regulates Subtype-Specific Motor Neuron Generation through Inhibition of Notch Signaling Priyanka Sabharwal, Changhee Lee, Sungjin Park, Meenakshi.

Auditory Hair Cell-Afferent Fiber Synapses Are Specialized to Operate at Their Best Frequencies M.E. Schnee, D.M. Lawton, D.N. Furness, T.A. Benke, A.J.

Neuronal Cell Types and Connectivity: Lessons from the Retina H. Sebastian Seung, Uygar Sümbül Neuron Volume 83, Issue 6, Pages (September 2014)

Single Units in the Medial Prefrontal Cortex with Anxiety-Related Firing Patterns Are Preferentially Influenced by Ventral Hippocampal Activity Avishek.

Synapse-Specific Adaptations to Inactivity in Hippocampal Circuits Achieve Homeostatic Gain Control while Dampening Network Reverberation Jimok Kim, Richard.

Pyramidal Neurons Grow Up and Change Their Mind Gord Fishell, Carina Hanashima Neuron Volume 57, Issue 3, Pages (February 2008) DOI: /j.neuron

Hippocampal Activity Patterns Carry Information about Objects in Temporal Context Liang-Tien Hsieh, Matthias J. Gruber, Lucas J. Jenkins, Charan Ranganath.

Mechanisms of Age-Related Macular Degeneration Jayakrishna Ambati, Benjamin J. Fowler Neuron Volume 75, Issue 1, Pages (July 2012) DOI: /j.neuron

Adaptation to Natural Binocular Disparities in Primate V1 Explained by a Generalized Energy Model Ralf M. Haefner, Bruce G. Cumming Neuron Volume 57, Issue.

Reading the Book of Memory: Sparse Sampling versus Dense Mapping of Connectomes H. Sebastian Seung Neuron Volume 62, Issue 1, Pages (April 2009)

Presynaptic Proteoglycans: Sweet Organizers of Synapse Development

Kelly Howell, Oliver Hobert Neuron

Forward and Back: Motifs of Inhibition in Olfactory Processing

Modulation of Electrotonic Coupling in the Inferior Olive by Inhibitory and Excitatory Inputs: Integration in the Glomerulus Jornt R. De Gruijl, Piotr A.

Volume 9, Issue 2, Pages (August 2011)

Looking for food in all the right places?

The Brain as an Efficient and Robust Adaptive Learner

Searching for Signatures of Brain Maturity: What Are We Searching For?

Should I Stay or Should I Go: Neuromodulators of Behavioral States

Dissonant Synapses Shall Be Punished

New Neurons Don’t Talk Back

Unravelling Spinal Circuits of Pain and Mechanical Allodynia

The Emerging Field of Neuroepigenetics

There's More Than One Way to Scale a Synapse

Volume 68, Issue 2, Pages (October 2010)

Only Two Ways to Achieve Perfection

Electrical Synapses: Rectification Demystified

A Remarkable Facilitating Effect of Parietal Damage

Learning about Synaptic GluA3

K+ Channel Regulation of Multicompartmental Signal Integration

Aligning a Synapse Neuron

Sacha B. Nelson, Vera Valakh Neuron

Ubiquitous Plasticity and Memory Storage

Ferret Interneurons Defy Expectations

The Strange Case of Aggression and the Brain

Optimizing Neural Information Capacity through Discretization

Principles Governing the Operation of Synaptic Inhibition in Dendrites

Mechanisms of Concerted Firing among Retinal Ganglion Cells

Yann Zerlaut, Alain Destexhe Neuron

Searching for Signatures of Brain Maturity: What Are We Searching For?

Gap junctions Current Biology

The Strange Case of Aggression and the Brain

Volume 91, Issue 6, Pages (September 2016)

The Timing Is Right for Cerebellar Learning

Volume 97, Issue 1, Pages (January 2018)

Proteins in Plant Brassinosteroid Signaling

Satb2 Stations Neurons along Reflex Arcs

Dendritic Ventriloquism: Inhibitory Synapses Throw Their Voices

Michael J. Higley, Bernardo L. Sabatini Neuron

Synaptic Plasticity, Engrams, and Network Oscillations in Amygdala Circuits for Storage and Retrieval of Emotional Memories Marco Bocchio, Sadegh Nabavi,

Cortical Cliques: A Few Plastic Neurons Get All the Action

Towards an Individualized Delineation of Functional Neuroanatomy

Neuronal Plasticity: How Do Neurons Know What To Do?

The Brain as an Efficient and Robust Adaptive Learner

The Back and Forth of Dendritic Plasticity

Pinning Down Randomness

Rapid Neocortical Dynamics: Cellular and Network Mechanisms

Volume 62, Issue 1, Pages (April 2009)

When Acetylcholine Unlocks Feedback Inhibition in Cortex

The Dopamine D2 Receptor: New Surprises from an Old Friend

Principles Governing the Operation of Synaptic Inhibition in Dendrites

David Hubel and Torsten Wiesel

Biological Functions of Activity-Dependent Transcription Revealed

Presentation transcript:

Enhanced Functions of Electrical Junctions Barry W. Connors, Timothy A. Zolnik, Seung-Chan Lee Neuron Volume 67, Issue 3, Pages 354-357 (August 2010) DOI: 10.1016/j.neuron.2010.07.024 Copyright © 2010 Elsevier Inc. Terms and Conditions

Figure 1 Electrical Synapses Preferentially Transmit Spike AHPs that Inhibit and Desynchronize the Local Network (A) Schematic three-neuron network electrically coupled by gap junctions with variable strengths (denoted by the number of gap junction channels). Only cell 1 receives excitatory synaptic input. (B) A spike in cell 1 triggers mainly hyperpolarizing electrical PSPs in cells 2 and 3. Because of the low-pass filtering properties of electrically coupled cell pairs, the slow AHP propagates much more readily than the high-frequency spike. Attenuation of the electrical PSP is proportional to gap junctional strength. (C) Under resting conditions, the three cells spike synchronously. When the excitatory synaptic input to cell 1 is activated (vertical dotted line), variably sized hyperpolarizing PSPs are generated in cells 2 and 3. Heterogeneous PSPs lead to transient desynchronization. With time, synchrony is reestablished. (Based on Vervaeke et al., 2010.) Neuron 2010 67, 354-357DOI: (10.1016/j.neuron.2010.07.024) Copyright © 2010 Elsevier Inc. Terms and Conditions