Volume 21, Issue 4, Pages (November 2014)

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Volume 21, Issue 4, Pages 257-265 (November 2014) Oxidative and proteolytic profiles of the right and left heart in a model of cancer-induced cardiac cachexia F.H. Borges, P.C. Marinello, A.L. Cecchini, F.P. Blegniski, F.A. Guarnier, R. Cecchini Pathophysiology Volume 21, Issue 4, Pages 257-265 (November 2014) DOI: 10.1016/j.pathophys.2014.05.003 Copyright © 2014 Elsevier B.V. Terms and Conditions

Fig. 1 Morphometric analysis of the ventricles showed reduced thickness, as indicated by the arrows. Control: representative heart section of a rat injected with phosphate-buffered saline in its right flank. T5: representative heart section of a rat injected with a suspension of 8.0×107 Walker-256 tumour cells and sacrificed after 5 days. T10: representative heart section of a rat injected with a suspension of 8.0×107 Walker-256 tumour cells and sacrificed after 10 days Pathophysiology 2014 21, 257-265DOI: (10.1016/j.pathophys.2014.05.003) Copyright © 2014 Elsevier B.V. Terms and Conditions

Fig. 2 Chemiluminescence induced by tert-butyl hydro peroxide on cardiac muscle of rats bearing Walker-256 tumours at different time points. The total curves were statistically compared by two-way ANOVA using the Bonferroni post hoc test. Each curve represents the mean of 8 animals; p<0.05 was considered significant. (A) p<0.05 when compared to the control group and (B) p<0.05 when compared to the 5-day group. Pathophysiology 2014 21, 257-265DOI: (10.1016/j.pathophys.2014.05.003) Copyright © 2014 Elsevier B.V. Terms and Conditions

Fig. 3 Quantification of carbonyl proteins in the cardiac muscle of rats bearing Walker-256 tumours at different time points. Results are expressed as mean±standard error of 8 animals. Control and experimental groups were compared by one-way ANOVA with Bonferroni's post hoc test; p<0.05 was considered significant. (A) p<0.05 when compared to control group and (B) p<0.05 when compared with 5-day group. Pathophysiology 2014 21, 257-265DOI: (10.1016/j.pathophys.2014.05.003) Copyright © 2014 Elsevier B.V. Terms and Conditions

Fig. 4 Quantification of thiobarbituric acid reactive substances on cardiac muscle of rats bearing Walker-256 tumours at different time points. Results are expressed as mean±standard error of 8 animals. Control and experimental groups were compared by one-way ANOVA using Bonferroni's post hoc test; p<0.05 was considered significant. (A) p<0.05 when compared to the control group and (B) p<0.05 when compared with the 5-day group. Pathophysiology 2014 21, 257-265DOI: (10.1016/j.pathophys.2014.05.003) Copyright © 2014 Elsevier B.V. Terms and Conditions

Fig. 5 Quantification of proteolytic capacity in cardiac muscle of rats bearing Walker-256 tumours at different time points. Results are expressed as percentage relative to control levels. Control and experimental groups were compared by one-way ANOVA using Bonferroni's post hoc test; p<0.05 was considered significant. (A) p<0.05 when compared to the control group and (B) p<0.05 when compared with the 5-day group. CTL: chymotrypsin-like proteolytic activity. Pathophysiology 2014 21, 257-265DOI: (10.1016/j.pathophys.2014.05.003) Copyright © 2014 Elsevier B.V. Terms and Conditions