Association of Exon 19 and 21 EGFR Mutation Patterns with Treatment Outcome after First-Line Tyrosine Kinase Inhibitor in Metastatic Non–Small-Cell Lung.

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Association of Exon 19 and 21 EGFR Mutation Patterns with Treatment Outcome after First-Line Tyrosine Kinase Inhibitor in Metastatic Non–Small-Cell Lung Cancer Victor H.F. Lee, FRCR, Vicky P.C. Tin, MMedSc, Tim-shing Choy, FRCR, Ka-on Lam, FRCR, Cheuk-wai Choi, MSc, Lap-ping Chung, DPhil, Janice W.H. Tsang, FRCP, Patty P.Y. Ho, FRCR, Dennis K.C. Leung, MRCP, Edmond S.K. Ma, MD, FRCPath, Jing Liu, PhD, Tony W.H. Shek, FRCPath, Dora L.W. Kwong, MD, To-wai Leung, MD, Maria P. Wong, MD, FRCPath Journal of Thoracic Oncology Volume 8, Issue 9, Pages 1148-1155 (September 2013) DOI: 10.1097/JTO.0b013e31829f684a Copyright © 2013 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 1 PFS for EGFR-mutated patients treated with first-line tyrosine kinase inhibitors. A, PFS for patients with different types of EGFR mutations. B, PFS for patients with either exon 19 deletion or L858R mutation. C, PFS for patients with different subtypes of exon 19 deletions. D, PFS for patients with subtypes of exon 19 deletions according to Gadzar's classification. E, PFS for patients with either L858R or L861Q/L861R mutation. EGFR, epidermal growth factor receptor; PFS, progression-free survival. Journal of Thoracic Oncology 2013 8, 1148-1155DOI: (10.1097/JTO.0b013e31829f684a) Copyright © 2013 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 2 OS for EGFR-mutated patients treated with first-line tyrosine kinase inhibitors. A, OS for patients different types of EGFR mutations. B, OS for patients with either exon 19 deletion or L858R mutation. C, OS for patients with different subtypes of exon 19 deletions. D, OS for patients with subtypes of exon 19 deletions according to Gadzar's classification. E, OS for patients with either L858R or L861Q/L861R mutation. EGFR, epidermal growth factor receptor; OS, overall survival. Journal of Thoracic Oncology 2013 8, 1148-1155DOI: (10.1097/JTO.0b013e31829f684a) Copyright © 2013 International Association for the Study of Lung Cancer Terms and Conditions