Antigen presentation of the immunodominant T-cell epitope of the major mugwort pollen allergen, Art v 1, is associated with the expression of HLA-DRB1∗01

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Presentation transcript:

Antigen presentation of the immunodominant T-cell epitope of the major mugwort pollen allergen, Art v 1, is associated with the expression of HLA-DRB1∗01 Beatrice Jahn-Schmid, PhD, Gottfried F. Fischer, MD, Barbara Bohle, PhD, Ingrid Faé, Gabriele Gadermaier, MSc, Azra Dedic, MSc, Fatima Ferreira, PhD, Christof Ebner, MD Journal of Allergy and Clinical Immunology Volume 115, Issue 2, Pages 399-404 (February 2005) DOI: 10.1016/j.jaci.2004.10.010 Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 1 Proliferation of Art v 125-36–specific TCCs (n=6) and TCLs (n=11) derived from 17 representative individuals in response to Art v 125-36 (first line) and truncated peptides in the presence of autologous APCs. Proliferation was assessed after 48 hours by [3H]thymidine uptake. +, Proliferation similar to the stimulation with Art v 125-36; −, no proliferation. Journal of Allergy and Clinical Immunology 2005 115, 399-404DOI: (10.1016/j.jaci.2004.10.010) Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 2 Proliferation of 6 TCCs with different TCRs derived from patient 5 in response to stimulation with peptides. A, Proliferation induced by Art v 125-36 (first line) or truncated peptides. B, Proliferation in response to the Art v 125-36 peptide (first line) and derivatives containing single amino acid substitutions. +, Proliferation similar to the stimulation with Art v 125-36; −, no proliferation; nt, not tested. Journal of Allergy and Clinical Immunology 2005 115, 399-404DOI: (10.1016/j.jaci.2004.10.010) Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 3 Illustration of clone-specific stimulation requirements. The minimal epitope (boxed sequence) and critical amino acids (gray) within the amino acid sequence of the immunodominant epitope Art v 125-36 are shown. Journal of Allergy and Clinical Immunology 2005 115, 399-404DOI: (10.1016/j.jaci.2004.10.010) Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 4 Presentation of Art v 125-36 by HLA-DRB1∗01 in 7 representative TCCs derived from 4 different individuals. Proliferation of Art v 125-36–specific TCCs in response to Art v 125-36 in the presence of autologous APCs (open bar) and an EBV cell line homozygous for HLA-DRB1∗01 (filled bar) is shown. HLA-DRB1 phenotypes are listed. Journal of Allergy and Clinical Immunology 2005 115, 399-404DOI: (10.1016/j.jaci.2004.10.010) Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions