From One to Many: Further Refinement of Medulloblastoma Subtypes Offers Promise for Personalized Therapy  Abhishek Bavle, D. Williams Parsons  Cancer Cell  Volume 31, Issue 6, Pages 727-729 (June 2017) DOI: 10.1016/j.ccell.2017.05.013 Copyright © 2017 Elsevier Inc. Terms and Conditions

Figure 1 Use of Similarity Network Fusion to Characterize the Intertumoral Heterogeneity of Medulloblastoma (A) Wnt, SHH, Group 3, and Group 4 are the four known molecular subgroups of medulloblastoma (MB). Similarity network fusion (SNF) was used to identify distinct subtypes within each subgroup. (B) There is wide variation in age at presentation and clinical outcomes (green, yellow, and red circles denote good, intermediate, and poor outcomes, respectively) for patients with SHH subgroup MB. SNF identified four distinct molecular subtypes within the SHH subgroup, each with characteristic age at presentation and clinical outcome. (C) Radiation can be avoided or deferred while maintaining good survival in young children with the DNMB/MBEN histology. The SHH γ subtype of MB occurs in young children and was associated with an excellent prognosis, irrespective of histopathology, potentially increasing the number of young patients for whom radiation might be reduced. Cancer Cell 2017 31, 727-729DOI: (10.1016/j.ccell.2017.05.013) Copyright © 2017 Elsevier Inc. Terms and Conditions