Long-Lived Plasma Cells Have a Sweet Tooth Lynn M. Corcoran, Stephen L. Nutt  Immunity  Volume 45, Issue 1, Pages 3-5 (July 2016) DOI: 10.1016/j.immuni.2016.07.003 Copyright © 2016 Elsevier Inc. Terms and Conditions

Figure 1 The Molecular and Cellular Components of the Long-Lived Plasma Cell Survival Niche Plasma cells are recruited to the bone marrow through their responsiveness to the chemokine CXCL12 and cellular adhesion molecules on bone marrow stromal cells. A variety of hematopoietic cell types, including eosinophils (shown), secrete the survival factors APRIL and IL-6. The transcription factors IRF4 and ZBTB20 are known to also control plasma cell survival. LLPC take up large amounts of glucose through their high expression of cell surface Glut1. Glucose is processed to fructose-6-phosphate, the majority of which is consumed by the hexosamine biosynthesis pathway during the glycosylation of antibody molecules, while a minority is converted to pyruvate, taken up into mitochondria by the transporter Mpc2, and used in respiration. Collectively, the high glucose uptake promotes LLPC survival and antibody secretion. Immunity 2016 45, 3-5DOI: (10.1016/j.immuni.2016.07.003) Copyright © 2016 Elsevier Inc. Terms and Conditions