Volume 73, Issue 5, Pages (March 2008)

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Volume 73, Issue 5, Pages 538-546 (March 2008) The RIFLE criteria and mortality in acute kidney injury: A systematic review Z. Ricci, D. Cruz, C. Ronco Kidney International Volume 73, Issue 5, Pages 538-546 (March 2008) DOI: 10.1038/sj.ki.5002743 Copyright © 2008 International Society of Nephrology Terms and Conditions

Figure 1 The RIFLE classification separates criteria for serum creatinine and urine output (UO). The criteria that lead to the worst possible classification should be used. RIFLE-F is present even if the increase in serum creatinine is below threefold, as long as the new serum creatinine is 4.0 mg per 100 ml or above in the setting of an acute increase of at least 0.5 mg per 100 ml. The shape of the figure denotes the fact that more patients (high sensitivity) will be included in the mild category, including some without actually having renal failure (less specificity). In contrast, at the bottom, the criteria are strict and therefore specific, but some patients will be missed. GFR, glomerular filtration rate; ARF, acute renal failure. From Bellomo et al.1 Kidney International 2008 73, 538-546DOI: (10.1038/sj.ki.5002743) Copyright © 2008 International Society of Nephrology Terms and Conditions

Figure 2 Forrest plot showing RR for death with respect to non-AKI patients.3-15 (a) Risk (RR=2.40; 58 073 participants included in meta-analysis), (b) Injury (RR=4.15; 55 351 participants included in meta-analysis), and (c) Failure (RR=6.37; 53 758 participants included in meta-analysis). Cr, creatinine; UO, urine output. See Table 2 for details. Kidney International 2008 73, 538-546DOI: (10.1038/sj.ki.5002743) Copyright © 2008 International Society of Nephrology Terms and Conditions

Figure 3 Details of included and excluded studies. Kidney International 2008 73, 538-546DOI: (10.1038/sj.ki.5002743) Copyright © 2008 International Society of Nephrology Terms and Conditions