Volume 11, Issue 3, Pages (December 2004)

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Volume 11, Issue 3, Pages 153-158 (December 2004) Mechanical stretch induces matrix metalloproteinase 1 production in human hepatic stellate cells Takashi Goto, Ken-ichiro Mikami, Kouich Miura, Shigetoshi Ohshima, Kazuo Yoneyama, Kunio Nakane, Daisuke Watanabe, Michiro Otaka, Sumio Watanabe Pathophysiology Volume 11, Issue 3, Pages 153-158 (December 2004) DOI: 10.1016/j.pathophys.2004.07.003 Copyright © 2004 Elsevier Ireland Ltd Terms and Conditions

Fig. 1 Phase-contrast microscopic views of LI90 cells. (A) Unstretched LI90 cells and (B) LI90 cells stretched for 24h. Stretched LI90 cells were narrower than unstretched cells and showed a finer network of processes. Pathophysiology 2004 11, 153-158DOI: (10.1016/j.pathophys.2004.07.003) Copyright © 2004 Elsevier Ireland Ltd Terms and Conditions

Fig. 2 Measurement of MMP1, MMP2, TIMP1, and TIMP2 in culture supernatants of LI90 cells. The concentration of MMP1 in culture supernatants showed an increase in stretched as opposed to unstretched LI90 cells (p<0.05), while in contrast the concentrations of MMP2, TIMP1, and TIMP2 showed a decrease in stretched cells compared to unstretched cells (p<0.05). Pathophysiology 2004 11, 153-158DOI: (10.1016/j.pathophys.2004.07.003) Copyright © 2004 Elsevier Ireland Ltd Terms and Conditions

Fig. 3 Measurement of MMP/TIMP ratios in culture supernatants of LI90 cells. MMP1/TIMP1 ratio and MMP1/TIMP2 ratio showed increase in stretched cells relative to unstretched cells (p<0.05). But MMP2/TIMP2 ratio and MMP2/TIMP1 ratio showed no significant difference between stretched and unstretched cells. Pathophysiology 2004 11, 153-158DOI: (10.1016/j.pathophys.2004.07.003) Copyright © 2004 Elsevier Ireland Ltd Terms and Conditions

Fig. 4 Measurement of 1CTP, PIIIP, and hyaluronic acid in culture supernatants of LI90 cells. Concentration of 1CTP, PIIIP, and hyaluronic acid in culture supernatants showed no significant difference between stretched and unstretched cells. Pathophysiology 2004 11, 153-158DOI: (10.1016/j.pathophys.2004.07.003) Copyright © 2004 Elsevier Ireland Ltd Terms and Conditions

Fig. 5 MMP1, MMP2, and TIMP1 mRNA expression of LI90 cells. The MMP1 mRNA expression/β-actin mRNA expression ratio was increased in stretched cells relative to unstretched cells (p<0.05). But MMP2, and TIMP1 mRNA expression showed no significant difference between stretched and unstretched cells. Pathophysiology 2004 11, 153-158DOI: (10.1016/j.pathophys.2004.07.003) Copyright © 2004 Elsevier Ireland Ltd Terms and Conditions