Remodeling KRAS Structure

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Presentation transcript:

Remodeling KRAS Structure Daniel J. Deredge, Patrick L. Wintrode Structure Volume 25, Issue 9, Pages 1323-1324 (September 2017) DOI: 10.1016/j.str.2017.08.012 Copyright © 2017 Elsevier Ltd Terms and Conditions

Figure 1 Structure of KRAS with Switch II Pocket Inhibitors and GDP A GDP bound KRAS structure (4OBE) in gray was superimposed with KRAS G12C structures bound to covalent inhibitors (5F2E in magenta, 4MLO in blue) binding in the switch II pocket. The switch II pocket conformation is color coded to the ligand (ARS853, magenta; vinylsulfonamide 7, blue). The G12C residue was rendered in yellow spherical representation. GDP is rendered in orange stick representation. Structure 2017 25, 1323-1324DOI: (10.1016/j.str.2017.08.012) Copyright © 2017 Elsevier Ltd Terms and Conditions