The selective serotonin reuptake inhibitor fluoxetine does not change rectal sensitivity and symptoms in patients with irritable bowel syndrome: A double.

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The selective serotonin reuptake inhibitor fluoxetine does not change rectal sensitivity and symptoms in patients with irritable bowel syndrome: A double blind, randomized, placebo-controlled study Sjoerd D. Kuiken, Guido N.J. Tytgat, Guy E.E. Boeckxstaens Clinical Gastroenterology and Hepatology Volume 1, Issue 3, Pages 219-228 (May 2003) DOI: 10.1016/S1542-3565(03)70039-1 Copyright © 2003 American Gastroenterological Association Terms and Conditions

Fig. 1 Individual thresholds (mm Hg above MDP) for discomfort/pain during phasic, isobaric rectal distention in 12 HV and 40 IBS patients with no active treatment (before intervention). Using the 10th percentile of HV as the lower limit of normal (≥25 mm Hg), 21 patients (53%) had a decreased threshold for discomfort/pain and were therefore considered hypersensitive to rectal distention. Clinical Gastroenterology and Hepatology 2003 1, 219-228DOI: (10.1016/S1542-3565(03)70039-1) Copyright © 2003 American Gastroenterological Association Terms and Conditions

Fig. 2 Effect of fluoxetine (▨) and placebo (□) on the threshold (mm Hg above MDP) for discomfort/pain during phasic, isobaric rectal distention in IBS patients. Data are expressed as means ± standard error of mean. No significant differences were observed. Clinical Gastroenterology and Hepatology 2003 1, 219-228DOI: (10.1016/S1542-3565(03)70039-1) Copyright © 2003 American Gastroenterological Association Terms and Conditions

Fig. 3 Bars representing the proportion of patients reporting significant abdominal pain (i.e., minimal 4 on a 1-5 scale) before and after 6 weeks of treatment with fluoxetine (▨) and placebo (□). *P < 0.05 by chi-square test. Clinical Gastroenterology and Hepatology 2003 1, 219-228DOI: (10.1016/S1542-3565(03)70039-1) Copyright © 2003 American Gastroenterological Association Terms and Conditions

Fig. 4 Evolution of individual thresholds for discomfort/pain during rectal distention studies before and after 6 weeks of treatment with placebo or fluoxetine. Normosensitive, patients characterized by normal sensitivity; and Hypersensitive, patients characterized by hypersensitivity to rectal distention. Clinical Gastroenterology and Hepatology 2003 1, 219-228DOI: (10.1016/S1542-3565(03)70039-1) Copyright © 2003 American Gastroenterological Association Terms and Conditions

Fig. 5 Bars representing the proportion of patients reporting significant abdominal pain (i.e., minimal 4 on a 1-5 scale) before and after 6 weeks of treatment with fluoxetine (▨) and placebo (□). Separate analysis was performed in hypersensitive and normosensitive patients. *P < 0.05 by chi-square test. Clinical Gastroenterology and Hepatology 2003 1, 219-228DOI: (10.1016/S1542-3565(03)70039-1) Copyright © 2003 American Gastroenterological Association Terms and Conditions