Suzanne M. Leal, Jurg Ott The American Journal of Human Genetics

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Effects of Stratification in the Analysis of Affected-Sib-Pair Data: Benefits and Costs Suzanne M. Leal, Jurg Ott The American Journal of Human Genetics Volume 66, Issue 2, Pages 567-575 (February 2000) DOI: 10.1086/302748 Copyright © 2000 The American Society of Human Genetics Terms and Conditions

Figure 1 Power to detect linkage at α=.001, for 100 ASPs. The ASPs were analyzed both unstratified and stratified into two groups (each with 50 ASPs) and five groups (each with 20 ASPs). The results shown are for IBD allele-sharing proportions of .52–.7. The American Journal of Human Genetics 2000 66, 567-575DOI: (10.1086/302748) Copyright © 2000 The American Society of Human Genetics Terms and Conditions

Figure 2 Power to detect linkage at α=.001, for 500 ASPs. The ASPs were analyzed unstratified and divided into two strata (each with 250 ASPs) and five strata (each with 100 ASPs). The proportion of IBD allele sharing in the first stratified ASP data set is displayed on the X-axis, and the proportion of IBD allele sharing in the other strata is .5. The proportions of IBD allele sharing for the unstratified groups are shown in parentheses; they are the weighted average of the IBD allele sharing for the two strata and the five strata, respectively. The American Journal of Human Genetics 2000 66, 567-575DOI: (10.1086/302748) Copyright © 2000 The American Society of Human Genetics Terms and Conditions

Figure 3 Power to detect linkage at α=.0001, for 200 ASPs. The ASPs were analyzed for linkage at locus 2, where the proportion of IBD allele sharing is .55, .6, and .65. The ASPs were then reanalyzed on the basis of their allele-sharing status at locus 1, where the proportion of IBD allele sharing is .6. The American Journal of Human Genetics 2000 66, 567-575DOI: (10.1086/302748) Copyright © 2000 The American Society of Human Genetics Terms and Conditions

Figure 4 Power to detect linkage at α=.0001, for 100 ASPs. The ASPs were analyzed for linkage at locus 2, where the proportion of IBD allele sharing is .55, .6, .65, and .7. The ASPs were then reanalyzed on the basis of their allele-sharing status at locus 1, where the proportion of IBD allele sharing is .6. The American Journal of Human Genetics 2000 66, 567-575DOI: (10.1086/302748) Copyright © 2000 The American Society of Human Genetics Terms and Conditions