Shining a LAMP on pauci-immune focal segmental glomerulonephritis

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Shining a LAMP on pauci-immune focal segmental glomerulonephritis Alan D. Salama, Charles D. Pusey Kidney International Volume 76, Issue 1, Pages 15-17 (July 2009) DOI: 10.1038/ki.2009.123 Copyright © 2009 International Society of Nephrology Terms and Conditions

Figure 1 Photomicrograph of a renal biopsy from a patient with active ANCA-associated vasculitis (AAV), demonstrating crescentic glomerulonephritis and fibrinoid necrosis in the glomerular tuft. Silver stain. Magnification × 400. Courtesy of Dr Candice Roufosse, Department of Histopathology, Hammersmith Hospital. Kidney International 2009 76, 15-17DOI: (10.1038/ki.2009.123) Copyright © 2009 International Society of Nephrology Terms and Conditions

Figure 2 Sketch demonstrating the proposed mechanism of molecular mimicry inducing immune responsiveness to bacterial fimbrial protein and in turn lysosomal-associated membrane protein (LAMP-2), resulting in activation of circulating neutrophils and damage to glomerular endothelial cells. Kidney International 2009 76, 15-17DOI: (10.1038/ki.2009.123) Copyright © 2009 International Society of Nephrology Terms and Conditions