Alan S. Rosman, MD, Mark A. Korsten, MD

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Presentation transcript:

Meta-analysis Comparing CT Colonography, Air Contrast Barium Enema, and Colonoscopy Alan S. Rosman, MD, Mark A. Korsten, MD The American Journal of Medicine Volume 120, Issue 3, Pages 203-210.e4 (March 2007) DOI: 10.1016/j.amjmed.2006.05.061 Copyright © 2007 Elsevier Inc. Terms and Conditions

Figure 1 sROC curves of 2 hypothetical tests. The test in (A) has good discrimination as determined by 3 hypothetic studies with the following pairs of sensitivities and specificities: 95% and 85%, 97% and 83%, and 85% and 95%, respectively. The test in (B) has poor discrimination as determined by 3 studies with the following pairs of sensitivities and specificities: 40% and 60%, 55% and 55%, and 60% and 40%, respectively. The sROC curves were constructed, and the exact AUC, homogenous AUC, and Q* index can be calculated. The homogeneous AUC is an approximation of the exact AUC that is easier to calculate. The index Q* is the point of the sROC curve in which the sensitivity equals the specificity. A perfect test has an exact AUC, homogeneous AUC, and index Q* values equal to 1, whereas a “worthless” test will have values equal to 0.5. For the test in (A), the exact AUC, homogeneous AUC, and index Q* are 0.963, 0.964, and 0.910, respectively. For the test in (B), the exact AUC, homogeneous AUC, and index Q* are 0.522, 0.522, and 0.517, respectively. The American Journal of Medicine 2007 120, 203-210.e4DOI: (10.1016/j.amjmed.2006.05.061) Copyright © 2007 Elsevier Inc. Terms and Conditions

Figure 2 sROC curve for CT colonography detecting polyps of any size; 95% CIs (dotted lines). 2D = 2-dimensional; 3D = 3-dimensional; CT = computed tomographic; BE = barium enema; AUC = area under the curve. The American Journal of Medicine 2007 120, 203-210.e4DOI: (10.1016/j.amjmed.2006.05.061) Copyright © 2007 Elsevier Inc. Terms and Conditions

Figure 3 sROC curve for CT colonography detecting polyps greater than 5 mm; 95% CIs (dotted lines). 2D = 2-dimensional; 3D = 3-dimensional; CT = computed tomographic; BE = barium enema; AUC = area under the curve. The American Journal of Medicine 2007 120, 203-210.e4DOI: (10.1016/j.amjmed.2006.05.061) Copyright © 2007 Elsevier Inc. Terms and Conditions

Figure 4 sROC curve for CT colonography detecting polyps greater than 10 mm; 95% CIs (dotted lines). 2D = 2-dimensional; 3D = 3-dimensional; CT = computed tomographic; BE = barium enema; AUC = area under the curve. The American Journal of Medicine 2007 120, 203-210.e4DOI: (10.1016/j.amjmed.2006.05.061) Copyright © 2007 Elsevier Inc. Terms and Conditions

Figure 5 sROC curve for colonoscopy detecting polyps greater than 5 mm. AUC = area under the curve. The American Journal of Medicine 2007 120, 203-210.e4DOI: (10.1016/j.amjmed.2006.05.061) Copyright © 2007 Elsevier Inc. Terms and Conditions

Figure 6 sROC curve for colonoscopy detecting polyps greater than 10 mm. AUC = area under the curve. The American Journal of Medicine 2007 120, 203-210.e4DOI: (10.1016/j.amjmed.2006.05.061) Copyright © 2007 Elsevier Inc. Terms and Conditions