Figure 2 Autophagosome formation in mammalian cells

Slides:

Advertisements

Similar presentations

Vesicular transport Dr. med. habil. Kőhidai László Assoc. Professor Depertment of Genetics, Cell- and Immunoibiology Semmelwesi University Semmelwesi University.

Advertisements

Tracking a protein through a cell. Organelles that Build Proteins Ribosomes, Endoplasmic Reticulum, Golgi Apparatus One of the most important jobs of.

Neurotransmitter Release. High voltage Low voltage.

Autophagy Part 1 Dr Aliwaini.

Autophagy in cancer biology and therapy Noor GAMMOH;Simon WILKINSON ;

Vesicular transport Dr. med. habil. Kőhidai László Assoc. Professor

Endoplasmic Reticulum Stress Promotes Autophagy and Apoptosis and Reduces Chemotherapy Resistance in Mutant p53 Lung Cancer Cells Cell Physiol Biochem.

Figure 2 Exosome composition

Interactions between Autophagy Receptors and Ubiquitin-like Proteins Form the Molecular Basis for Selective Autophagy Vladimir Rogov, Volker Dötsch,

Sustaining Proliferative Signaling and Evading Growth Suppressors

Regulation of inflammasomes by autophagy

TGFb –Superfamily Proteins

Figure 2 The unfolded protein response

You have identified a novel cytoplasmic protein

Figure 5 Lipid droplet consumption

Figure 1 mTOR pathway activation

Autophagy Receptors and Neurodegenerative Diseases

Figure 1 The machinery of autophagy

Innate and Adaptive Immunity through Autophagy

Volume 140, Issue 7, Pages (June 2011)

Figure 3 Defects in the T cell receptor signalling pathway

Figure 1 HCV life cycle and site of action of DAAs

Figure 2 Oestrogen receptor signalling pathways

Figure 1 ER stress and associated lines of defence

Figure 3 Physiological regulation of autophagy in the heart

Nat. Rev. Gastroenterol. Hepatol. doi: /nrgastro

Figure 1 mTOR complex biology

Development of PI3K/AKT/mTOR Pathway Inhibitors and Their Application in Personalized Therapy for Non–Small-Cell Lung Cancer Vassiliki Papadimitrakopoulou,

Jing Zhang, Thomas M. Roberts, Ramesh A. Shivdasani Gastroenterology

Atomistic Autophagy: The Structures of Cellular Self-Digestion

Identification of TOR Signaling Complexes

Figure 1 The insulin signalling pathway

Figure 6 Possible therapeutic targets to decrease hepatic steatosis

Inhibition of mammalian target of rapamycin: Two goals with one shot?

Autophagosome formation and Ubiquitin-like conjugation pathway

A Role for Ubiquitin in Selective Autophagy

Autophagy in kidney disease and aging: lessons from rodent models

Douglas R. Green, Beth Levine Cell

Membrane Traffic: Trans-Golgi Tethers Leave a Surprisingly Small GAP

Autophagy in the Pathogenesis of Disease

Gabriel Mitchell, Ralph R. Isberg Cell Host & Microbe

Amino acid-dependent regulation of autophagy by mTORC1

A Dimer to Bridge Early Autophagosomal Membranes

Live Longer sans the AT1A Receptor

Figure 4 Amino-acid-dependent mTORC1 activation

Figure 3 Selective autophagy related to liver metabolism

Autophagy Shows Its Animal Side

Chapter 48 Cellular and Molecular Basis of Neurodegeneration in the

Figure 1 The mTOR signalling pathway

Youry Kim, Jenny L. Anderson, Sharon R. Lewin Cell Host & Microbe

Volume 93, Issue 5, Pages (March 2017)

The Role of Lipids in the Control of Autophagy

Nucleophagy: A New Look at Past Observations

Autophagy protects proximal tubular cells from injury and apoptosis

Not All Autophagy Membranes Are Created Equal

Autophagy, Immunity, and Microbial Adaptations

The Process of Autophagy

Autophagy in liver diseases: Time for translation?

What’s Eating the Epidermis

The Cytoskeleton–Autophagy Connection

Chapter 13 Intracellular Vesicular Traffic.

Tobias B. Huber, Gerd Walz, E Wolfgang Kuehn Kidney International

Autophagy in the Cellular Energetic Balance

Autophagosome Formation: Cutting the Gordian Knot at the ER

Autophagy and the Integrated Stress Response

Multisubunit Tethering Complexes and Their Role in Membrane Fusion

Autophagy: Renovation of Cells and Tissues

Insulin-stimulated glucose and potassium transport in skeletal muscle.

A, Targeting Atg4b in the tumor and in the host.

Il Nobel per la medicina 2016 alle scoperte sulla "pulizia cellulare"

Presentation transcript:

Figure 2 Autophagosome formation in mammalian cells Figure 2 | Autophagosome formation in mammalian cells. Induction of autophagy activates the serine/threonine- protein kinase ULK1 complex, which translocates to sites near the endoplasmic reticulum. The ULK1 complex in turn regulates the class III phosphatidylinositol 3-kinase (PI3K) complex. The multi-membrane spanning protein autophagy-related protein 9A (ATG9L) is involved in an early stage of autophagosome formation. Formation of phosphatidylinositol 3-phosphate (PI3P) recruits zinc finger FYVE domain-containing protein 1 (DFCP1) and promotes the formation of the omegasome. Other PI3P-binding WIPI (WD repeat domain phosphoinositide-interacting protein) family proteins, the ATG12–ATG5–ATG16L complex and the microtubule-associated proteins 1A/1B light chain (LC3)–phosphatidylethanolamine (PE) conjugate have important roles in the elongation and closure of the isolation membrane. LC3 is synthesized in a precursor form (pro-LC3) and cleaved at the C-terminus by ATG4B, becoming a mature form (LC3-I). LC3-I is conjugated to PE through ATG conjugating systems. LC3–PE is referred to as LC3-II. Fusion between the autophagosome and lysosome is mediated by the SNARE proteins syntaxin 17 (STX17), synaptosomal-associated protein 29 (SNAP-29) and vesicle-associated membrane protein 8 (VAMP8). ATG14, a component of the class III PI3K complex, facilitates this fusion event through direct binding to the STX17–SNAP-29 complex. Pleckstrin homology domain-containing family M member 1 (PLEKHM1), which can associate with Ras-related protein RAB7A, homotypic fusion and protein sorting complex (HOPS), and LC3, also accelerates membrane fusion. ER, endoplasmic reticulum; mLST8, target of rapamycin complex subunit LST8; RAPTOR, regulatory-associated protein of mTOR; VPS15, phosphatidylinositol 3-kinase regulatory subunit type 3; VPS34, phosphatidylinositol 3-kinase catalytic subunit type 3. Ueno, T. & Komatsu, M. (2017) Autophagy in the liver: functions in health and disease Nat. Rev. Gastroenterol. Hepatol. doi:10.1038/nrgastro.2016.185