Sensors of Succinate: Neural Stem Cell Grafts Fight Neuroinflammation

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Sensors of Succinate: Neural Stem Cell Grafts Fight Neuroinflammation Zaal Kokaia, Olle Lindvall Cell Stem Cell Volume 22, Issue 3, Pages 283-285 (March 2018) DOI: 10.1016/j.stem.2018.01.019 Copyright © 2018 Elsevier Inc. Terms and Conditions

Figure 1 Transplantation of NSCs or iNSCs in an Animal Model of Multiple Sclerosis Leads to Reduced Pathology and Functional Improvements Red color depicts a multiple sclerosis (MS) model with activation of immune cells (microglia and MDMs), release of succinate, and detrimental outcome of inflammation. Blue color illustrates events induced by transplantation of NSC or iNSCs: decreased levels of macrophage-derived succinate, release of anti-inflammatory PGE2 from NSC/iNSCs, switch of pro- to anti-inflammatory activity of macrophages, and overall suppression of the pro-inflammatory environment. Cell Stem Cell 2018 22, 283-285DOI: (10.1016/j.stem.2018.01.019) Copyright © 2018 Elsevier Inc. Terms and Conditions