Membranous-like glomerulopathy with masked IgG kappa deposits

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Membranous-like glomerulopathy with masked IgG kappa deposits

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Membranous-like glomerulopathy with masked IgG kappa deposits Christopher P. Larsen, Josephine M. Ambuzs, Stephen M. Bonsib, Christie L. Boils, L. Nicholas Cossey, Nidia C. Messias, Fred G. Silva, Yihan H. Wang, Neriman Gokden, Patrick D. Walker Kidney International Volume 86, Issue 1, Pages 154-161 (July 2014) DOI: 10.1038/ki.2013.548 Copyright © 2014 International Society of Nephrology Terms and Conditions

Figure 1 Glomerular deposits in membranous-like glomerulopathy with masked IgG-κ deposits (MGMIDs). (a) Brightly fuchsinophilic subepithelial deposits (arrows) are evident on this Masson trichrome stain from patient 11 (original magnification × 600). (b) Segmental spikes are present along the glomerular basement membranes by Jones methenamine silver stain in patient 6 (original magnification × 400). Kidney International 2014 86, 154-161DOI: (10.1038/ki.2013.548) Copyright © 2014 International Society of Nephrology Terms and Conditions

Figure 2 Immunofluorescence findings from membranous-like glomerulopathy with masked IgG-κ deposit (MGMID) patient 11. Glomeruli stain negative for IgG by routine immunofluorescence on fresh tissue (a) and positive on paraffin-embedded tissue after pronase digestion (b) (direct immunofluorescence; original magnification × 400). Glomeruli show staining for κ (c) and not λ (d) on the pronase-digested tissue (direct immunofluorescence; original magnification × 400). Kidney International 2014 86, 154-161DOI: (10.1038/ki.2013.548) Copyright © 2014 International Society of Nephrology Terms and Conditions

Figure 3 Electron-dense deposits of membranous-like glomerulopathy with masked IgG-κ deposits (MGMIDs). (a) A large hump-like subepithelial deposit is present along with subepithelial deposits more typical of membranous glomerulopathy in patient 4 (unstained, original magnification × 12,000). (b) Numerous subepithelial deposits typical of membranous glomerulopathy are present in patient 9 (unstained, original magnification × 12,000). Kidney International 2014 86, 154-161DOI: (10.1038/ki.2013.548) Copyright © 2014 International Society of Nephrology Terms and Conditions