Volume 151, Issue 4, Pages (April 2017)

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Volume 151, Issue 4, Pages 740-743 (April 2017) COUNTERPOINT: Should Inhaled Antibiotic Therapy Be Used Routinely for the Treatment of Bacterial Lower Respiratory Tract Infections in the ICU Setting? No Marin H. Kollef, MD, FCCP CHEST Volume 151, Issue 4, Pages 740-743 (April 2017) DOI: 10.1016/j.chest.2016.11.007 Copyright © 2016 American College of Chest Physicians Terms and Conditions

Figure 1 Serum or tissue antibiotic concentration assessed over time after delivery. Drug concentrations less than the minimum inhibitory concentration (MIC) suggest that the pathogen is not susceptible, and first-step resistant mutants will not be inhibited. Drug concentrations between the MIC and the mutation prevention concentration (MPC) suggest that the pathogen is susceptible but that first-step resistant mutants will not be inhibited. Antibiotic concentrations greater than the MPC will achieve susceptibility for the pathogen as well as inhibit first-step mutant strains. The table provides estimates of the epithelial lining fluid antibiotic concentrations after parenteral administration).9 ELF = epithelial lining fluid. CHEST 2017 151, 740-743DOI: (10.1016/j.chest.2016.11.007) Copyright © 2016 American College of Chest Physicians Terms and Conditions

Figure 2 Aerosol deposition in the oropulmonary space according to generated particle size. CHEST 2017 151, 740-743DOI: (10.1016/j.chest.2016.11.007) Copyright © 2016 American College of Chest Physicians Terms and Conditions