Lysosomes Current Biology Lena Wartosch, Nicholas A. Bright, J. Paul Luzio  Current Biology  Volume 25, Issue 8, Pages R315-R316 (April 2015) DOI: 10.1016/j.cub.2015.02.027 Copyright © 2015 Elsevier Ltd Terms and Conditions

Figure 1 Lysosome fusion. Lysosomes fuse with late endosomes to form endolysosomes, which are major sites of acid hydrolase activity and the digestion of endocytosed cargo. Equivalent fusions of lysosomes with phagosomes or autophagosomes can also occur (not shown in detail). Lysosomes can be re-formed from endolysosomes and autolysosomes via poorly understood fission and maturation processes. Traffic routes from the trans-Golgi network (TGN) deliver newly synthesized proteins to endosomes and lysosomes. Current Biology 2015 25, R315-R316DOI: (10.1016/j.cub.2015.02.027) Copyright © 2015 Elsevier Ltd Terms and Conditions