Pharmacology, Physiology, and Mechanisms of Incretin Hormone Action

Slides:

Advertisements

Similar presentations

Mitoconfusion: Noncanonical Functioning of Dynamism Factors in Static Mitochondria of the Heart Moshi Song, Gerald W. Dorn Cell Metabolism Volume 21, Issue.

Advertisements

Making Proteins in the Powerhouse B. Martin Hällberg, Nils-Göran Larsson Cell Metabolism Volume 20, Issue 2, Pages (August 2014) DOI: /j.cmet

Eph-Ephrin Bidirectional Signaling in Physiology and Disease Elena B. Pasquale Cell Volume 133, Issue 1, Pages (April 2008) DOI: /j.cell

Human Brown Adipose Tissue Sven Enerbäck Cell Metabolism Volume 11, Issue 4, Pages (April 2010) DOI: /j.cmet Copyright © 2010.

The Metabolic Basis of Pulmonary Arterial Hypertension Gopinath Sutendra, Evangelos D. Michelakis Cell Metabolism Volume 19, Issue 4, Pages (April.

Germline Energetics, Aging, and Female Infertility Jonathan L. Tilly, David A. Sinclair Cell Metabolism Volume 17, Issue 6, Pages (June 2013) DOI:

Oxygen Sensors at the Crossroad of Metabolism Julián Aragonés, Peter Fraisl, Myriam Baes, Peter Carmeliet Cell Metabolism Volume 9, Issue 1, Pages

The ART of Lowering Ceramides

Volume 14, Issue 2, Pages (August 2011)

Biology of Incretins: GLP-1 and GIP

Ghrelin—a new player in glucose homeostasis?

Immunological Goings-on in Visceral Adipose Tissue

Insulin Release: Shedding Light on a Complex Matter

Jochen G. Schneider, Joseph H. Nadeau Cell Metabolism

Novel SIRT1 Mutation Linked to Autoimmune Diabetes in Humans

ERRγ—A New Player in β Cell Maturation

More Than Satiety: Central Serotonin Signaling and Glucose Homeostasis

Pancreatic β cells: Responding to the matrix

Volume 12, Issue 5, Pages (November 2010)

Volume 24, Issue 3, Pages (September 2016)

Safia Costes, Peter C. Butler Cell Metabolism

A Clock Ticks in Pancreatic β Cells

Gal3 Links Inflammation and Insulin Resistance

Volume 15, Issue 1, Pages (January 2012)

The Cardiovascular Biology of Glucagon-like Peptide-1

A Radical Role for p38 MAPK in Tumor Initiation

Immunological Goings-on in Visceral Adipose Tissue

Is Predisposition to NAFLD and Obesity Communicable?

VEGF-B Improves Metabolic Health through Vascular Pruning of Fat

High T Gives β Cells a Boost

Independent Control of Aging and Axon Regeneration

Volume 26, Issue 1, Pages 6-7 (July 2017)

The CAMplexities of Central Ghrelin

Treating Obesity? It's in the Bag!

Life Is Short, if Sweet Cell Metabolism

Volume 7, Issue 6, Pages (June 2008)

Autophagy: A Sweet Process in Diabetes

Imbalanced Insulin Actions in Obesity and Type 2 Diabetes: Key Mouse Models of Insulin Signaling Pathway Tetsuya Kubota, Naoto Kubota, Takashi Kadowaki

[Br]eaking FAt Cell Volume 159, Issue 2, Pages (October 2014)

E Proteins Enforce Security Checkpoints in the Thymus

IL-6 Muscles In on the Gut and Pancreas to Enhance Insulin Secretion

Pancreatic β Cell Regeneration as a Possible Therapy for Diabetes

NRG4: An Endocrine Link between Brown Adipose Tissue and Liver

VEGF-B Improves Metabolic Health through Vascular Pruning of Fat

Beyond Energy Homeostasis: the Expanding Role of AMP-Activated Protein Kinase in Regulating Metabolism David Carling, Benoit Viollet Cell Metabolism

Chengcheng Jin, Jorge Henao-Mejia, Richard A. Flavell Cell Metabolism

Is Growth Hormone Resistance/IGF-1 Reduction Good for You?

Lasker Lauds Leptin Cell Metabolism

Lung Cancer Resets the Liver’s Metabolic Clock

Pancreas and Not Gut Mediates the GLP-1-Induced Glucoincretin Effect

Volume 27, Issue 4, Pages (April 2018)

Do Cancer Cells Care If Their Host Is Hungry?

Speaking from the Heart: Systemic Copper Signaling

Volume 24, Issue 4, Pages (October 2016)

The Cardiovascular Biology of Glucagon-like Peptide-1

Volume 14, Issue 2, Pages (August 2011)

Volume 13, Issue 4, Pages (April 2011)

Anna B. Osipovich, Mark A. Magnuson Cell Stem Cell

Adipose Dendritic Cells Come Out of Hiding

An IRKO in the Podo: Impaired Insulin Signaling in Podocytes and the Pathogenesis of Diabetic Nephropathy Susan B. Gurley, Thomas M. Coffman Cell Metabolism

Ann Marie Schmidt, Kathryn J. Moore Cell Metabolism

Deciphering Pancreatic Islet β Cell and α Cell Maturation Pathways and Characteristic Features at the Single-Cell Level Wei-Lin Qiu, Yu-Wei Zhang, Ye.

Oxytocin: The Neuropeptide of Love Reveals Some of Its Secrets

Role reversal: Brain insulin and liver STAT3

Unlikely partners in weight loss?

Should I Stay or Should I Go: A Clash of α-Cell Identity

Of Mice and Men: Not ExAKTly the Same?

Ringing the dinner bell for insulin: Muscarinic M3 receptor activity in the control of pancreatic β cell function Jesper Gromada, Thomas E. Hughes Cell.

Estrogens and Obesity: Is It All in Our Heads?

Presentation transcript:

Pharmacology, Physiology, and Mechanisms of Incretin Hormone Action Jonathan E. Campbell, Daniel J. Drucker Cell Metabolism Volume 17, Issue 6, Pages 819-837 (June 2013) DOI: 10.1016/j.cmet.2013.04.008 Copyright © 2013 Elsevier Inc. Terms and Conditions

Figure 1 Direct Pharmacological Actions of GLP-1R Agonists GLP-1R agonists act directly via the GLP-1R on pancreatic islets, heart, intestine, subpopulations of immune cells, kidney, and brain. Cell Metabolism 2013 17, 819-837DOI: (10.1016/j.cmet.2013.04.008) Copyright © 2013 Elsevier Inc. Terms and Conditions

Figure 2 Indirect Pharmacological Effects of GLP-1R Agonists Activation of GLP-1R signaling pathways in the brain leads to biological actions in the liver, adipose, and gastrointestinal tract. Cell Metabolism 2013 17, 819-837DOI: (10.1016/j.cmet.2013.04.008) Copyright © 2013 Elsevier Inc. Terms and Conditions

Figure 3 Physiological Roles of Endogenous GLP-1 The biological actions of GLP-1 as revealed by loss-of-function studies utilizing Glp1r−/− mice or antagonists of the GLP-1R are shown and summarized in the accompanying table. Cell Metabolism 2013 17, 819-837DOI: (10.1016/j.cmet.2013.04.008) Copyright © 2013 Elsevier Inc. Terms and Conditions

Figure 4 GLP-1 Signal Transduction Pathways in the Pancreatic β Cell Recent studies delineating roles for β-arrestin-1, β-catenin, and IGF-1R signaling in the effects of GLP-1 on insulin secretion, β cell growth, and function are illustrated. Cell Metabolism 2013 17, 819-837DOI: (10.1016/j.cmet.2013.04.008) Copyright © 2013 Elsevier Inc. Terms and Conditions

Figure 5 Biological Actions of GIP The direct and indirect actions of GIP on target tissues are illustrated. Cell Metabolism 2013 17, 819-837DOI: (10.1016/j.cmet.2013.04.008) Copyright © 2013 Elsevier Inc. Terms and Conditions