A Double-Blind, Randomized, Crossover Comparison Between Single-Dose and Double-Dose Immediate-Release Oral Morphine at Bedtime in Cancer Patients Ola.

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A Double-Blind, Randomized, Crossover Comparison Between Single-Dose and Double-Dose Immediate-Release Oral Morphine at Bedtime in Cancer Patients Ola Dale, MD, PhD, Maria Piribauer, MD, Stein Kaasa, MD, PhD, Kristin Moksnes, MD, Heidi Knobel, MD, PhD, Pål Klepstad, MD, PhD Journal of Pain and Symptom Management Volume 37, Issue 1, Pages 68-76 (January 2009) DOI: 10.1016/j.jpainsymman.2007.12.016 Copyright © 2009 U.S. Cancer Pain Relief Committee Terms and Conditions

Fig. 1 CONSORT flow sheet. Journal of Pain and Symptom Management 2009 37, 68-76DOI: (10.1016/j.jpainsymman.2007.12.016) Copyright © 2009 U.S. Cancer Pain Relief Committee Terms and Conditions

Fig. 2 Time course of serum concentrations (nmol/L) of morphine (upper panel) and M6G (lower panel) after SD and DD morphine. The individual variation is indicated by the median (minimum–maximum) morphine concentrations (nmol/L) at time 0: SD 25 (6–96); DD 21 (8–80), and similarly for M6G: SD 175 (28–455); DD: 139 (28–646). Journal of Pain and Symptom Management 2009 37, 68-76DOI: (10.1016/j.jpainsymman.2007.12.016) Copyright © 2009 U.S. Cancer Pain Relief Committee Terms and Conditions