Benjamin A. Rybicki, José L. Walewski, Mary J

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Presentation transcript:

The BTNL2 Gene and Sarcoidosis Susceptibility in African Americans and Whites Benjamin A. Rybicki, José L. Walewski, Mary J. Maliarik, Hamed Kian, Michael C. Iannuzzi The American Journal of Human Genetics Volume 77, Issue 3, Pages 491-499 (September 2005) DOI: 10.1086/444435 Copyright © 2005 The American Society of Human Genetics Terms and Conditions

Figure 1 Level of association between sarcoidosis and variation in the exon/intron 5 region of BTNL2 on the basis of the three-SNP haplotype window moving across the region. The three study samples analyzed include 219 African American nuclear families (blackened circles), 295 African American case-control pairs (unblackened circles), and 366 white case-control pairs (unblackened squares). The American Journal of Human Genetics 2005 77, 491-499DOI: (10.1086/444435) Copyright © 2005 The American Society of Human Genetics Terms and Conditions

Figure 2 A, Incomplete disequilibrium (as measured by 1-D′) between allele pairs of HLA-DRB1 and the four BTNL2 exon/intron 5 haplotype-tagging SNPs (G16043A [rs9268480], A16071G [rs2076530], G16113T, and T16165C) in whites with sarcoidosis and matched controls (n=260 pairs). B, Incomplete disequilibrium (as measured by 1-D′) between allele pairs of HLA-DRB1 and the four BTNL2 exon/intron 5 haplotype-tagging SNPs (G16043A [rs9268480], A16071G [rs2076530], G16113T, and T16165C) in African Americans with sarcoidosis and matched controls (n=187 pairs). The American Journal of Human Genetics 2005 77, 491-499DOI: (10.1086/444435) Copyright © 2005 The American Society of Human Genetics Terms and Conditions