Volume 39, Issue 2, Pages (August 2003)

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Volume 39, Issue 2, Pages 286-289 (August 2003) Novel mutation in ferroportin 1 gene is associated with autosomal dominant iron overload Anne-Marie Jouanolle, Véronique Douabin-Gicquel, Chantal Halimi, Olivier Loréal, Patricia Fergelot, Thierry Delacour, Anne-Sophie de Lajarte-Thirouard, Bruno Turlin, Jean-Yves Le Gall, Estelle Cadet, Jacques Rochette, Véronique David, Pierre Brissot Journal of Hepatology Volume 39, Issue 2, Pages 286-289 (August 2003) DOI: 10.1016/S0168-8278(03)00148-X

Fig. 1 Family pedigree. Affected members are indicated by filled symbols (the arrow shows the proband). Dates of birth are mentioned between the parentheses. Journal of Hepatology 2003 39, 286-289DOI: (10.1016/S0168-8278(03)00148-X)

Fig. 2 Histopathological study of hepatic iron overload by Perl's staining. (A) A strong cytoplasmic iron overload, visible as blue granules, is clearly shown in hepatocytes. Note the predominant localisation of iron deposits close to the biliary canaliculi (arrow) (original magnification ×400). (B) Major iron deposits are also found in Kupffer cells (arrowhead). In addition, aggregates of non-parenchymal cells (arrow), likely Kupffer cells, which are strongly overloaded, are also found in the hepatic lobule. Dashed arrow: presence of iron in the pericaniliculi area of the hepatocytes (original magnification ×400). (C) Portal space with the presence of iron deposits in cells (arrow), likely macrophages, whereas iron deposits were only slight in endothelial cells (dashed arrow) and not detected in biliary cells (small arrow) (original magnification ×250). Journal of Hepatology 2003 39, 286-289DOI: (10.1016/S0168-8278(03)00148-X)